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Development of a Gene Edited Next-Generation Hematopoietic Cell Transplant to Enable Acute Myeloid Leukemia Treatment by Solving Off-Tumor Toxicity

John R. Lydeard,Michelle I. Lin,Huanying Gary Ge,Amanda Halfond,Shu Wang,Mark B. Jones,Julia Etchin,Gabriella Angelini,Juliana Xavier-Ferrucio,Jessica Lisle,Kienan Salvadore,Yonina Keschner,Hannah Mager,Julian Scherer,Jianxin Hu,Siddhartha Mukherjee,Tirtha Chakraborty

Molecular Therapy - Methods &amp Clinical Development（2023）

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关键词
acute myeloid leukemia,immunotherapy,CRISPR-Cas9,hematopoietic stem cell,CD33,genome engineering,IND-enabled,pharmacology/toxicology
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