Distinguishment Of Patients With Mesangial Proliferative Glomerulonephritis From Healthy Subjects By Urine Volatile Metabolites

Aims: Urinary volatile organic compound (VOCs) has received growing interest because it was convenient and non-invasive and it can successfully provide unique biomarker profiles for many diseases, especially in cancers. Materials and methods: Urinary samples were collected from 16 MsPGN patients and 15 healthy controls. Solid phase microextraction-chromatography-mass spectrometry (SPME-GC-MS) was used to analyse the urinary metabolites. The principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLSDA) were performed to deal with the data. Results: Six specific VOCs biomarkers were present at decreased levels in the urine of MsPGN patients. These VOCs included pyrrole, 2-pentanone, 4-heptanone, silanediol, dimethyl-and carbamic acid, a monoammonium salt. Conclusions: These significant decreases indicate that they are potential biomarkers for distinguishing the differences between MsPGN and healthy subjects.