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    • Author Correction: Targeted NUDT5 Inhibitors Block Hormone Signaling in Breast Cancer Cells

    Nature communications（2019）SCI 1区

    Science for Life Laboratory | Centre de Regulació Genòmica (CRG) | Department of Biochemistry and Biophysics | Uppsala University Drug Optimization and Pharmaceutical Profiling Platform | Chemical Biology Consortium Sweden

    Cited 2|Views5
    Abstract
    An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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    Key words
    Breast cancer,Drug discovery and development,Screening,Target validation,Science,Humanities and Social Sciences,multidisciplinary
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    【要点】：本文报道了一种针对NUDT5的抑制剂，能够阻断乳腺癌细胞中的激素信号，具有潜在的抗癌治疗作用。
    

    【方法】：作者通过分子对接和动力学模拟方法，设计并筛选出具有潜在抑制活性的NUDT5抑制剂。
    

    【实验】：实验在乳腺癌细胞系MCF-7中进行，使用的数据集为抑制剂对NUDT5活性的抑制效果数据，结果显示NUDT5抑制剂能够有效阻断激素信号，抑制乳腺癌细胞生长。
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