Nicholas Valerie - Karolinska Institutet

基本信息

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个人简介

Developing innovative cellular target engagement methodologies for assessing ligand binding and mechanism of action and a recent convert to the power of proximity-inducing small molecules.

研究兴趣

论文共 34 篇作者统计合作学者相似作者

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Probing intracellular determinants of PARP inhibitor selectivity and pharmacology with CeTEAM

Maria J. Pires,Alen Lovric,Emanuele Fabbrizi,Dante Rotili,Mikael Altun,Nicholas C.K. Valerie

biorxiv（2024）

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Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

Nicholas C.K. Valerie,Kumar Sanjiv,Oliver Mortusewicz,Si Min Zhang,Seher Alam, Maria J. Pires, Hannah Stigsdotter,Azita Rasti,Marie-France Langelier,Daniel Rehling,Adam Throup,Matthieu Desroses, Jacob Onireti,Prasad Wakchaure,Ingrid Almlöf,Johan Boström,Luka Bevc, Giorgia Benzi,Pål Stenmark,John M. Pascal,Thomas Helleday,Brent D.G. Page,Mikael Altun

biorxiv（2024）

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Supplementary Figure Legends 1-4 from Inhibition of Neurotensin Receptor 1 Selectively Sensitizes Prostate Cancer to Ionizing Radiation

Nicholas C.K. Valerie,Eli V. Casarez,John O. DaSilva,Marya E. Dunlap-Brown,Sarah J. Parsons,George P. Amorino,Jaroslaw Dziegielewski

crossref（2023）

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Supplementary Figure 2 from Inhibition of Neurotensin Receptor 1 Selectively Sensitizes Prostate Cancer to Ionizing Radiation

Nicholas C.K. Valerie,Eli V. Casarez,John O. DaSilva,Marya E. Dunlap-Brown,Sarah J. Parsons,George P. Amorino,Jaroslaw Dziegielewski

crossref（2023）

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Supplementary Figure Legend from ATM Kinase Inhibition Preferentially Sensitizes P53-Mutant Glioma to Ionizing Radiation

Laura Biddlestone-Thorpe, Muhammad Sajjad,Elizabeth Rosenberg,Jason M. Beckta,Nicholas C.K. Valerie, Mary Tokarz,Bret R. Adams,Alison F. Wagner,Ashraf Khalil,Donna Gilfor,Sarah E. Golding,Sumitra Deb,David G. Temesi, Alan Pak Tao Lau, Mark J. O’Connor,Kevin S. Choe,Luis F. Parada,Sang Kyun Lim,Nitai D. Mukhopadhyay,Kristoffer Valerie

openalex（2023）

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Supplementary Data from Improved ATM Kinase Inhibitor KU-60019 Radiosensitizes Glioma Cells, Compromises Insulin, AKT and ERK Prosurvival Signaling, and Inhibits Migration and Invasion

Sarah E. Golding,Elizabeth Rosenberg,Nicholas C.K. Valerie, Isa M. Hussaini,Mark Frigerio,Xiaoling Cockcroft,Wei Yee Chong,Marc Hummersone,Laurent Rigoreau,Keith Menear, Mark J. O’Connor,Lawrence F. Povirk,Timothy Van Meter,Kristoffer Valerie

openalex（2023）

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Supplementary Table 3 from ATM Kinase Inhibition Preferentially Sensitizes P53-Mutant Glioma to Ionizing Radiation

Laura Biddlestone-Thorpe, Muhammad Sajjad,Elizabeth Rosenberg,Jason M. Beckta,Nicholas C.K. Valerie, Mary Tokarz,Bret R. Adams,Alison F. Wagner,Ashraf Khalil,Donna Gilfor,Sarah E. Golding, Sumitra Deb,David G. Temesi,Alan Lau,Mark J. O'Connor,Kevin S. Choe,Luis F. Parada,Sang Kyun Lim,Nitai D. Mukhopadhyay,Kristoffer Valerie

openalex（2023）

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Supplementary Figure 4 from ATM Kinase Inhibition Preferentially Sensitizes P53-Mutant Glioma to Ionizing Radiation

Laura Biddlestone-Thorpe, Muhammad Sajjad,Elizabeth Rosenberg,Jason M. Beckta,Nicholas C.K. Valerie, Mary Tokarz,Bret R. Adams,Alison F. Wagner,Ashraf Khalil,Donna Gilfor,Sarah E. Golding, Sumitra Deb,David G. Temesi, Alan Lau, Mark J. O'Connor,Kevin S. Choe,Luis F. Parada,Sang Kyun Lim,Nitai D. Mukhopadhyay,Kristoffer Valerie

openalex（2023）

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NUDT15-mediated Hydrolysis Limits the Efficacy of Anti-Hcmv Drug Ganciclovir

Si Min Zhang,Daniel Rehling,Ann-Sofie Jemth,Adam Throup,Natalia Landazuri,Ingrid Almlof,Mona Gottmann,Nicholas C. K. Valerie,Sanjay R. Borhade,Prasad Wakchaure,Brent D. G. Page,Matthieu Desroses,Evert J. Homan,Martin Scobie,Sean G. Rudd,Ulrika Warpman Berglund,Cecilia Soderberg-Naucler,Pal Stenmark,Thomas Helleday

Cell chemical biologyno. 12 (2021): 1693-1702.e6

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