A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling.
Angewandte Chemie(2018)
摘要
The direct union of primary, secondary, and tertiary carboxylic acids with a chiral glyoxylate-derived sulfinimine provides rapid access into a variety of enantiomerically pure α-amino acids (>85 examples). Characterized by operational simplicity, this radical-based reaction enables the modular assembly of exotic α-amino acids, including both unprecedented structures and those of established industrial value. The described method performs well in high-throughput library synthesis, and has already been implemented in three distinct medicinal chemistry campaigns.
更多查看译文
关键词
amino acid synthesis,decarboxylative radical addition,library synthesis,redox-active esters,synthetic methods
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要