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The focus of the research is to determine the mechanisms by which human teratogens induce congenital malformations. The model system that is utilized is the purple sea urchin, Strongylocentrotus purpuratus. The rationale for using this animal model is that it has a well-characterized early developmental gene regulatory network (GRN). The value of a defined developmental GRN is that it gives a specific set of molecular interactions as to how specific cell types in the embryo develop. It is hypothesized that the molecular targets of human teratogens will be conserved in the sea urchin since homologous signaling molecules and transcription factors are found during early development of the two organisms. However, anatomical conservation is clearly not maintained. It is interesting to note that many human teratogens perturb early sea urchin development. Gene expression in the early embryo can be determined by a technique that yields a direct count of the number of mRNA molecules in the embryo (Nanostring nCounter). The value of this procedure is that it gives very accurate and reproducible mRNA levels in biological samples (sea urchin embryos). The capacity to interpret transcriptomic data via the GRN allows a temporal as well as spatial interaction map that describes the relationship between the nodes in the GRN, thus providing information regarding the initial perturbation event. Metabolomic studies have also been performed to characterize perturbations in early sea urchin development by human teratogens. It is hypothesized that one of the major impediments to determining teratogenic mechanisms is that there is a lack of understanding of the normal embryonic development of the standard laboratory animal models and thus it is difficult to determine when a perturbation from normal development has occurred.
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Papers共 141 篇Author StatisticsCo-AuthorSimilar Experts
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Acoustics '91 (2024)
Christopher P. Ashcroft, Alexander M. Berne, Florian Blasberg, Kelly Catlin,Michael R. Collins, Doug J. Critcher,Jean-Nicolas Desrosiers,Adam Goetz,Cheryl Hayward, Ricky A. Jones,Michael J. Karmilowicz,Nandell Keene,Carlos A. Martinez,Sebastien Monfette, Sebastian David Pattavina,Hahdi H. Perfect,John A. Ragan, Blake Rauschenberger,Neal W. Sach, Gemma Scotney,Scott C. Sutton, Courtney Talicska,Steven J. R. Twiddle, Jared Van Haitsma, Richard Wisdom
ORGANIC PROCESS RESEARCH & DEVELOPMENTno. 6 (2024): 2260-2268
Xu-cheng Gan,Benxiang Zhang,Nathan Dao,Cheng Bi, Maithili Pokle, Liyan Kan,Michael R. Collins, Chet C. Tyrol,Philippe N. Bolduc, Michael Nicastri,Yu Kawamata,Phil S. Baran,Ryan Shenvi
Yu Wang,Cheng Bi,Yu Kawamata,Lauren N. Grant,Lacey Samp,Paul F. Richardson,Shasha Zhang,Kaid C. Harper,Maximilian D. Palkowitz,Aristidis Vasilopoulos,Michael R. Collins,Martins S. Oderinde, Chet C. Tyrol, Doris Chen, Erik A. Lachapelle,Jake B. Bailey,Jennifer X. Qiao,Phil S. Baran
NATURE CHEMISTRYno. 9 (2024)
Natureno. 7988 (2023): 745-751
Rebecca A. Gallego,Louise Bernier, Hui Chen,Sujin Cho-Schultz,Loanne Chung,Michael Collins,Matthew Del Bel,Jeff Elleraas, Cinthia Costa Jones,Ciaran N. Cronin,Martin Edwards, Xu Fang,Timothy Fisher,Mingying He,Jacqui Hoffman, Ruiduan Huo,Mehran Jalaie,Eric Johnson,Ted W. Johnson,Robert S. Kania,Manfred Kraus,Jennifer Lafontaine,Phuong Le, Tongnan Liu, Michael Maestre,Jean Matthews,Michele McTigue,Nichol Miller, Qiming Mu,Xulong Qin,Shijian Ren,Paul Richardson,Allison Rohner,Neal Sach,Li Shao,Graham Smith,Ruirui Su, Bin Sun,Sergei Timofeevski,Phuong Tran,Shuiwang Wang,Wei Wang,Ru Zhou,Jinjiang Zhu,Sajiv K. Nair
Maximilian D Palkowitz,Gabriele Laudadio,Simon Kolb,Jin Choi,Martins S Oderinde,Tamara El-Hayek Ewing,Philippe N Bolduc,TeYu Chen,Hao Zhang,Peter T W Cheng,Benxiang Zhang,Michael D Mandler, Vanna D Blasczak,Jeremy M Richter,Michael R Collins, Ryan L Schioldager,Martin Bravo,T G Murali Dhar,Benjamin Vokits,Yeheng Zhu,Pierre-Georges Echeverria,Michael A Poss,Scott A Shaw,Sebastian Clementson,Nadia Nasser Petersen,Pavel K Mykhailiuk,Phil S Baran
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Author Statistics
#Papers: 144
#Citation: 6151
H-Index: 34
G-Index: 77
Sociability: 6
Diversity: 3
Activity: 20
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