Research Interests
The research in my group focuses on the development and application of advanced imaging-based approaches to quantitatively probe the biophysical chemistry of chromatin dynamics at the single-cell level. In particular, we are interested in understanding how molecular processes related to chromatin structure, accessibility, and expression are organized and regulated in space and time. By integrating approaches from optical microscopy and spectroscopy, genome and protein engineering, and computational analysis, our work aims to illuminate the physico-chemical driving forces that underpin the spatio-temporal heterogeneities in chromatin dynamics, as well as the physiological implications of their misregulation in human diseases.