基本信息
浏览量:137
职业迁徙
个人简介
Growth factors and their transmembrane receptors contribute to all steps of tumor progression, from the initial phase of clonal expansion, through angiogenesis to metastasis. Hence, the information relay system involved in growth factor signaling provides potential sites for signal interception and tumor inhibition.
A relevant example comprises the epidermal growth factor (EGF) and the respective receptor tyrosine kinase, namely ErbB-1/EGFR, which belongs to a prototype signaling module that drives carcinoma development. The extended module includes two autonomous receptor, EGFR and ErbB-4, and two non-autonomous receptors, namely: a ligand-less oncogenic receptor, HER2/ErbB-2, and a kinase-dead receptor (ErbB-3). This signaling module is richly involved in human cancer and already serves as a target for several cancer drugs.
Due to the inherent complexity and a large amount of experimental data, we proposed a systems approach to understanding ErbB signaling. EGF - to - ErbB signaling is envisioned as a bow-tie configured, evolvable network, sharing modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable tradeoff of robustness, systems level understanding is expected to identify therapeutic opportunities for targeting aberrant activation of the network in human pathologies.
A relevant example comprises the epidermal growth factor (EGF) and the respective receptor tyrosine kinase, namely ErbB-1/EGFR, which belongs to a prototype signaling module that drives carcinoma development. The extended module includes two autonomous receptor, EGFR and ErbB-4, and two non-autonomous receptors, namely: a ligand-less oncogenic receptor, HER2/ErbB-2, and a kinase-dead receptor (ErbB-3). This signaling module is richly involved in human cancer and already serves as a target for several cancer drugs.
Due to the inherent complexity and a large amount of experimental data, we proposed a systems approach to understanding ErbB signaling. EGF - to - ErbB signaling is envisioned as a bow-tie configured, evolvable network, sharing modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable tradeoff of robustness, systems level understanding is expected to identify therapeutic opportunities for targeting aberrant activation of the network in human pathologies.
研究兴趣
论文共 285 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
C. -R Pradeep, A. Zeisel, W. J. Köstler,M. Lauriola,J. Jacob-Hirsch,B. Haibe-Kains,N. Amariglio, N. Ben-Chetrit,A. Emde, I. Solomonov, G. Neufeld, M. Piccart,
Shir Nevo, Noga Frenkel,Noam Kadouri, Tom Gome, Noa Rosenthal,Tal Givony,Ayelet Avin, Cristina Peligero Cruz,Merav Kedmi,Moshit Lindzen, Shifra Ben Dor, Golda Damari,
SCIENCE IMMUNOLOGYno. 91 (2024): eabq6930-eabq6930
引用0浏览0WOS引用
0
0
Nature Biomedical Engineeringno. 1 (2023): 1-15
Ilaria Marrocco,Suvendu Giri,Arturo Simoni-Nieves, Nitin Gupta, Anna Rudnitsky,Yuya Haga,Donatella Romaniello,Arunachalam Sekar, Mirie Zerbib,Roni Oren,Moshit Lindzen,Damon Fard,
Molecular cellno. 18 (2023): 3333-3346.e5
NATURE COMMUNICATIONSno. 1 (2023)
Özlem Yilmaz Sümer, Korbinian Schelzig,Janine Jung,Xiaoya Li, Janina Moros, Luisa Schwarzmüller, Ezgi Şen Demirdöğen, Sabine Karolus, Angelika Wörner,Nishanth Belugali Nataraj, Efstathios–Iason Vlachavas,Clarissa Gerhäuser,
Research Square (Research Square) (2023)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn