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个人简介
Dr. Chen's Research focuses on the genetic control of vertebrate organogenesis. His particular interests include the role of homeobox genes and growth factors in the epithelial-mesenchymal interactions that lead to organ formation. One major project studies molecular mechanisms of tooth initiation and patterning. Currently, the project involves identifying genes involved in vertebrate tooth initiation and their expression regulation, studying the origin of tooth developmental potential, studying the patterning of incisor and molar teeth and genes involved in this process and studying the molecular basis of recombinant tooth formation (a model for tooth regeneration). Dr. Chen's research also studies the molecular basis of non-syndromic cleft palate caused by gene mutations in mammals. Cleft palate is one of the most frequent congenital birth defects in human being. It occurs annually with a frequency of 1 in 700 to 1,000 live births among individuals of European descent. Non-syndromic cleft palate arises from genetic or environmental perturbation in the multi-step process of palate development. Similar to human beings, mutations in the Msx1 gene cause non-sydromic cleft palate in mice. The lab is currently examining the role of Msx1, Dlx1, Dlx2, Bmps, Shh and Fgfs in mouse palatogenesis. Dr. Chen's work includes research on the molecular basis of situs inversus in vertebrate animals. Situs inversus occurs with a frequency of one out of 8,000 live births in humans. It was just recently demonstrated that positioning of internal organs is regulated by a cascade of genetic pathways involving a number of genes. Dr. Chen's lab has been studying the role of transcription factor Pitx2 in the regulation of heart looping. They have recently cloned two novel genes in the chick that show a potential involvement in left-right asymmetric determination during early embryonic development. Functional analyses of these two genes are in progress.
研究兴趣
论文共 1018 篇作者统计合作学者相似作者
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Xi Zheng, Xiaoying Chen,Xiaoxiao Hu,Lidan Chen, Nana Mi, Qianqian Zhong, Linfang Wang,Chensheng Lin,Yiping Chen,Fancai Lai,Xuefeng Hu,Yanding Zhang
JOURNAL OF PATHOLOGYno. 3 (2024): 320-333
Yun Gong,Mohammad Haeri, Xiao Zhang,Yisu Li,Anqi Liu, Di Wu, Qilei Zhang, S Michal Jazwinski,Xiang Zhou, Xiaoying Wang, Lindong Jiang,Yi-Ping Chen,
medRxiv : the preprint server for health sciences (2024)
COMMUNICATIONS BIOLOGYno. 1 (2024): 385-385
Zih-An Chen,Cheng-Hsun Wu,Si-Han Wu,Chiung-Yin Huang,Chung-Yuan Mou, Kuo-Chen Wei,Yun Yen, I-Ting Chien, Sabiha Runa,Yi-Ping Chen,Peilin Chen
ACS nano (2024)
Tsung- Hsu,Yi-Ping Chen, Rong-Lin Zhang, Zih-An Chen,Cheng-Hsun Wu,Wen-Chang Chang,Chung-Yuan Mou, Hardy Wai-Hong Chan,Si-Han Wu
ACS APPLIED MATERIALS & INTERFACES (2024)
Therapeutic Apheresis and Dialysisno. 4 (2023): 720-725
BMC pediatricsno. 1 (2023): 264-8
International Journal of Biological Sciencesno. 15 (2023): 4833-4833
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