Research Interests Ion channels in reproduction and development Signaling mechanisms underlying tissue repair and regeneration Publications Sun X, Ruan YC, Guo J, Chen H, Tsang LL, Zhang X. Jiang X and Chan HC (2014), Regulation of miR-101/miR-199a-3p by the epithelial sodium channel during embryo implantation: involvement of CREB phosphorylation, Reproduction 148: 559-568 Ruan YC, Wang Y, Da Silva N, Kim B, Diao RY, Hill E, Brown D, Chan HC and Breton S (2014), CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway, Journal of cell science 127: 4396-4408 Guo JH, Chen H, Ruan YC, Zhang XL, Zhang XH, Fok KL, Tsang LL, Yu MK, Huang WQ, Sun X, Chung YW, Jiang X, Sohma Y and Chan HC (2014), Glucose-induced electrical activities and insulin secretion in pancreatic islet beta-cells are modulated by CFTR, Nature communications 5: 4420 Chan HC, Jiang X and Ruan YC (2014), Emerging role of cystic fibrosis transmembrane conductance regulator as an epigenetic regulator: linking environmental cues to microRNAs, Clinical and experimental pharmacology and physiology 41: 615-622 Fok KL, Chen H, Ruan YC and Chan HC (2014), Novel regulators of spermatogenesis, Seminars in cell and developmental biology 29: 31-42 Ruan YC, Chen H and Chan HC (2014), Ion channels in the endometrium: regulation of endometrial receptivity and embryo implantation, Human reproduction update 20: 517-529 Roy JW, Hill E, Ruan YC, Vedovelli L, Paunscu TG, Brown D and Breton S (2013), Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in caput epididymis, American journal of physiology cell physiology 305: C436-446 Krapf D, Ruan YC, Wertheimer EV, Battistone MA, Pawlak JB, Sanjay A, Pilder SH, Cuasnicu P, Breton S and Visconti PE (2012), cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit, Developmental biology 369: 43-53