Yamini Dalal

My lab focuses on proteins called histones and their variants, which package the entirety of the human genome into a nucleoprotein complex called chromatin in vivo. Specific regions of chromatin are prone to fragility and chromosomal rearrangements in cancer cells. Using a combinatorial toolset, we continue our investigations into the functional consequences of histone variant-driven chromatin alterations within the cancer epigenome, and the therapeutic potential of small molecule suppressors.