Xue-Kun Guo

The intestinal Epithelia is the first line of host defense against intestinal microbial invasion. However, if the microbes overgrow or translocate into intestinal tissues, the gut inflammation may develop. So the IECs bear an important mission to establish a strong mucosal barrier to segregate these microbes. Current research interests cover the topics in intestinal epithelial cell maintaining microbiota colonization, host defense against bacterial invasion, and maintenance of gut homeostasis.