We are interested in understanding cortical plasticity and reorganization in traumatic brain injury, posttraumatic epilepsy, and neuropathic pain, and developing novel treatments and prevention for these diseases. A major direction we have been focusing on is to test the role of homeostatic activity regulation in the mechanism and treatment of posttraumatic epilepsy and neuropathic pain. Other ongoing projects include determining the role of HMGB1 signaling in the development and prevention of posttraumatic epilepsy and studying cortical plasticity after traumatic brain injury. In addition, we explore the effects of acupuncture and traditional Chinese medicine on these diseases.