William J Dower

2022-Present. Scientific Advisor, Medikine, Inc. Menlo Park, CA 2010-2022 Founder and Chief Scientific Officer; Medikine, Inc. Menlo Park, CA 2008-2009 XenoPort Fellow; XenoPort, Inc. Santa Clara, CA 1999-2008 Founder and Vice President, Discovery Biology; XenoPort, Inc. Santa Clara, CA 1995-1999 Senior Director, Molecular Biology; Affymax Research Institute, Palo Alto, CA. 1992-1994 Director of Molecular Biology: Affymax Research Institute Palo Alto, CA 1991–1992 Senior Scientist, Molecular Biology; Affymax Research Institute, Palo Alto, CA 1989–1990 Staff Scientist, Molecular Biology; Affymax Research Institute, Palo Alto, CA 1984-1989 Senior Research Biochemist and Project Scientist; Bio-Rad Laboratories, Richmond, CA 1982–1983 Research Associate, Biological Sciences; Stanford University, Stanford, CA 1978–1981 Postdoctoral Research Fellow, Biological Sciences; Stanford University, Stanford, CA (Dr. R. T. Schimke). 1973–1977 Graduate Student, Reproductive Biology; Harvard Medical School, Boston, MA (Dr. K.J. Ryan) 1971–1973 Graduate Student, Biology; University of California, San Diego, CA (Dr K.J. Ryan) 1970 –1971 Research Assistant, Reproductive Medicine; School of Medicine, University of California, San Diego, CA US Patents (most recent 25) 50) US 7,037,706 Ronald W Barrett;. William J. Dower; Mark Gallop; Thomas F. Woiwode; Steven E. Cwirla; Compounds displayed on replicable genetic packages and methods of using same. May 2, 2006. (XenoPort) 51) US 7,056,666 William J Dower, Stephen PA Fodor. Analysis of surface immobilized polymers utilizing microfluorescence detection. June 6, 2006. (Affymetrix) 52) US 7,091,311. William J. Dower; Barrett; Ronald W. Cwirla; Steven E. Duffin; David J., Gates; Christian M. Haselden; Sherril S. Mattheakis; Larry C.,Schatz; Peter J., Wagstrom; Christopher R. Wrighton; Nicholas C. Peptides and compounds that bind to a receptor. August 15, 2006. (Affymax) 53) US 7,192,720. William J Dower; Cwirla, Steven E. Array-based, epitope-captured antibody display. March 20, 2007. (XenoPort) 54) US 7,229,757. Barrett; Ronald W. William J Dower; Gallop; Mark; Woiwode; Thomas F. Cwirla, Steven E. Compounds displayed on icosahedral phage and methods of using same. June 12, 2007. (XenoPort) 55) US7,329,496. William J Dower, Stephen PA Fodor. Sequencing of surface immobilized polymers utilizing microflourescence detection. Feb 12, 2008. (Affymetrix) 56) US 7,413,536. William J. Dower, Mark A. Gallop; Ronald W. Barrett; Kenneth C. Cundy; Tania Chernov-Rogan. Substrates and screening methods for transport proteins. Aug. 19, 2008. (XenoPort) 57) US 7,459,275. Willliam J. Dower, Stephen SPA Fodor. Sequencing of surface immobilized polymers utilizing microfluorescence detection. Dec 2, 2008. (Affymetrix) 58) US 7,507,546. Noa Zerangue; Tracy Dias; William J. Dower; Methods of screening agents, conjugates or conjugate moieties for transport by a PEPT2 transporter. Mar. 24, 2009. (XenoPort) 59) US 7,517,643. Ronald W. Barrett; William J. Dower; Mark Gallop; Thomas F. Woiwode Steven E. Cwirla. Compounds displayed on replicable genetic packages and methods of using same. Apr. 14, 2009. (XenoPort) 60) US 7,534,574. William J. Dower; Steven E. Cwirla. Epitope-captured antibody display. May 19, 2009. (XenoPort) 61) US 7,553,617. William J. Dower, Steven E Cwirla. Peptide library and screening systems. .un 30, 2009. (Affymax) 62) US 7,683,043. Noa Zerangue, Qingzhi Gao, William J. Dower. Creatine phosphate analog prodrugs, compositions and uses therof. Mar 23, 2010. (XenoPort) 63) US 7,741,062. William J Dower, Steven E Cwirla. Epitope-captured antibody display. Jun. 22, 2010. (XenoPort) 64) US 7,919,454. Noa Zerangue, Tracy Dias, William J Dower. Methods of treatment using conjugates transported by a PEPT2 transporter. April 5, 2011. (XenoPort) 65) US 8,202,852. Noa Zerangue, Quingzhi Gao, William J Dower. Creatine phosphate analog pro-drugs, compositions and uses thereof. June 19, 2012. (Affymax/GSK) 66) US 8,227,422. William J Dower, Ronald W Barrett, Steven W Cwirla, David J Duffin, Christian M Gates, Sherril S Haselden, Larry C Mattheakis, Peter J Schatz, Christopher R Wagstrom, Nicholas,C Wrighton. Peptides and compounds that bind to a receptor. July 24, 2012. 67) US10,689,417-B2. William J Dower, Michael C Needels, Ronald W Barrett, Alice V. Bakker, Steven E Cwirla. IL-2R.gamma binding compounds. June 23, 2020 68) US10,703,776-B2. William J Dower, Michael C Needels, Ronald W Barrett, Alice V. Bakker, Steven E Cwirla. IL-2R beta binding compounds. July 7, 2020 69) US11,248,025-B2. William J Dower, Michael C Needels, Ronald W Barrett, Alice V. Bakker, Steven E Cwirla. IL-2alpha receptor subunit binding compounds. Feb 15, 2022 (Medikine 70) US11,248,030-B2. William J Dower, Michael C Needels, Ronald W Barrett, Alice V. Bakker, Steven E Cwirla. Dual IL-2R and IL-7R binding