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职业迁徙
个人简介
Research
TRANSLATIONAL IMMUNOLOGY emphasizing on discovering and translating the novel discoveries in the field of immunology to the delivery of effective immunological solutions for human diseases is my long-standing interest.
Humanized Mouse Model: My laboratory has established the humanized mice with complete human immune system. Using humanized mice, we have successfully established different disease models, such as virus infection, tumors, graft-versus-host disease (GVHD), allograft transplantation and lung fibrosis models. Now we are focusing on establishment of different autoimmune disease models in humanized mice.
Viral Immunology: To understand cellular and molecular basis involved in the host immune responses to influenza viruses and Epstein-Barr virus (EBV) and develop novel antiviral strategies. We have report for the first time that the small-for-gestational-age and preterm neonates have impaired antiviral activity of Vγ9Vδ2-T and NK cells against influenza virus. By targeting human gd-T cell immunity, we have further discovered novel strategies to treat human and avian influenza diseases and control EBV-induced tumors. Now we are studying the roles of gd-T and NK cells in immune surveillance of influenza virus and EBV infections.
Transplantation Immunology: To understand the basic processes that control T-cell-mediated inflammation and tolerance. We have developed the novel methods to generate antigen-specific CD4 and CD8 regulatory T cells (Tregs). We also confirmed that ex vivo-generated human CD8 Tregs can control graft-versus-host disease (GVHD) in an allo-specific manner while leaving graft versus tumor and general immune responses intact in humanized mice. We are now focusing on translating these basic studies into the development of new therapies for GVHD, organ transplantation and autoimmune diseases.
TRANSLATIONAL IMMUNOLOGY emphasizing on discovering and translating the novel discoveries in the field of immunology to the delivery of effective immunological solutions for human diseases is my long-standing interest.
Humanized Mouse Model: My laboratory has established the humanized mice with complete human immune system. Using humanized mice, we have successfully established different disease models, such as virus infection, tumors, graft-versus-host disease (GVHD), allograft transplantation and lung fibrosis models. Now we are focusing on establishment of different autoimmune disease models in humanized mice.
Viral Immunology: To understand cellular and molecular basis involved in the host immune responses to influenza viruses and Epstein-Barr virus (EBV) and develop novel antiviral strategies. We have report for the first time that the small-for-gestational-age and preterm neonates have impaired antiviral activity of Vγ9Vδ2-T and NK cells against influenza virus. By targeting human gd-T cell immunity, we have further discovered novel strategies to treat human and avian influenza diseases and control EBV-induced tumors. Now we are studying the roles of gd-T and NK cells in immune surveillance of influenza virus and EBV infections.
Transplantation Immunology: To understand the basic processes that control T-cell-mediated inflammation and tolerance. We have developed the novel methods to generate antigen-specific CD4 and CD8 regulatory T cells (Tregs). We also confirmed that ex vivo-generated human CD8 Tregs can control graft-versus-host disease (GVHD) in an allo-specific manner while leaving graft versus tumor and general immune responses intact in humanized mice. We are now focusing on translating these basic studies into the development of new therapies for GVHD, organ transplantation and autoimmune diseases.
研究兴趣
论文共 208 篇作者统计合作学者相似作者
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Jaime S. Rosa Duque,Samuel M. S. Cheng,Carolyn A. Cohen,Daniel Leung,Xiwei Wang,Xiaofeng Mu,Yuet Chung, Tsun Ming Lau,Manni Wang,Wenyue Zhang,Yanmei Zhang,Howard H. W. Wong,Leo C. H. Tsang,Sara Chaothai,Tsz Chun Kwan,John K. C. Li,Karl C. K. Chan,Leo L. H. Luk, Jenson C. H. Ho,Wing Yan Li,Amos M. T. Lee,Jennifer H. Y. Lam,Sau Man Chan,Wilfred H. S. Wong,Issan Y. S. Tam,Masashi Mori,Sophie A. Valkenburg,Malik Peiris,Wenwei Tu,Yu Lung Lau
WORLD JOURNAL OF PEDIATRICSno. 4 (2024): 353-370
Eugene Yu-hin Chan,Daniel Leung,Samuel M. S. Cheng,Jaime S. Rosa Duque,Xiaofeng Mu,Fanny Tsz-Wai Ho,Pak-chiu Tong,Wai-Ming Lai,Matthew H.L. Lee,Stella Chim,Issan Y. S. Tam,Leo C. H. Tsang,Kelvin K. H. Kwan,Yuet Chung,Howard H. W. Wong,Amos M. T. Lee,Wing Yan Li, Summer T.K. Sze,Jennifer H. Y. Lam,Derek H.L. Lee,Sau Man Chan,Wenwei Tu,Malik Peiris,Alison Lap Tak,Yu Lung Lau
Kidney international reportsno. 10 (2023): 2177-2179
Daniel Leung,Carolyn A. Cohen,Xiaofeng Mu,Jaime S. Rosa Duque,Samuel M. S. Cheng,Xiwei Wang,Manni Wang,Wenyue Zhang,Yanmei Zhang,Issan Y. S. Tam,Jennifer H. Y. Lam,Sau Man Chan,Sara Chaothai,Kelvin K. H. Kwan,Karl C. K. Chan,John K. C. Li,Leo L. H. Luk,Leo C. H. Tsang, Nym Coco Chu,Wilfred H. S. Wong,Masashi Mori,Wing Hang Leung,Sophie Valkenburg,Malik Peiris,Wenwei Tu,Yu Lung Lau
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGYno. 2 (2023): e13735-e13735
Pediatric Discoveryno. 1 (2023)
Daniel Leung,Eugene Yu -hin Chan,Xiaofeng Mu,Jaime S. Rosa Duque,Samuel M. S. Cheng,Fanny Tsz-wai Ho,Pak-chiu Tong,Wai-ming Lai, Matthew H. L. Lee,Stella Chim,Issan Y. S. Tam,Leo C. H. Tsang,Kelvin K. H. Kwan,Yuet Chung,Howard H. W. Wong,Amos M. T. Lee,Wing Yan Li, Summer T. K. Sze,Jennifer H. Y. Lam,Derek H. L. Lee,Sau Man Chan,Wenwei Tu,Malik Peiris,Alison Lap-tak Ma,Yu Lung Lau
Xiaolu Wang,Ming Yue,Jason Pui Yin Cheung,Prudence Wing Hang Cheung,Yanhui Fan, Meicheng Wu, Xiaojun Wang,Sen Zhao,Anas M. Khanshour,Jonathan J. Rios,Zheyi Chen,Xiwei Wang,Wenwei Tu,Danny Chan,Qiuju Yuan,Dajiang Qin,Guixing Qiu,Zhihong Wu,Terry Jianguo Zhang,Shiro Ikegawa,Nan Wu,Carol A. Wise,Yong Hu,Keith Dip Kei Luk,You-Qiang Song, Bo Guo
The Journal of clinical investigation/The journal of clinical investigation (2023)
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作者统计
#Papers: 208
#Citation: 7673
H-Index: 52
G-Index: 79
Sociability: 7
Diversity: 0
Activity: 1
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