Dr. Guida’s main research interests include the design of inhibitors of enzymes in signal transduction pathways and the biosynthetic pathways of polyamines and lipids.These inhibitors have potential utility as drugs for the treatment of cancer and infectious diseases.The discovery, design and synthesis of non-covalent, copper-based 20S proteasome inhibitors for the treatment of cancer is also an area of significant interest to Dr. Guida’s group.