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Germ cells, preimplantation embryos and pluripotent stem cells at first glance seem to have nothing in common. A more careful look, though, reveals that they are very closely linked to each other. The zygote originates from the fusion of two highly specialized germ cells (the sperm and the oocyte) and in a few days develops into a blastocyst with a pluripotent cell population (the inner cell mass). These cells diverge from the extraembryonic cells of the trophoectoderm and can give rise to embryonic stem cells, in which a perpetual pluripotent and undifferentiated state is maintained.
Germ cells, preimplantation embryos and pluripotent stem cells at first glance seem to have nothing in common. A more careful look, though, reveals that they are very closely linked to each other. The zygote originates from the fusion of two highly specialized germ cells (the sperm and the oocyte) and in a few days develops into a blastocyst with a pluripotent cell population (the inner cell mass). These cells diverge from the extraembryonic cells of the trophoectoderm and can give rise to embryonic stem cells, in which a perpetual pluripotent and undifferentiated state is maintained.
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论文共 87 篇作者统计合作学者相似作者
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Alec McQuiston, Junbao Yang, Jason Romero, Naveen Bojjireddy, Travis McQuiston,Vittorio Sebastiano, Mustafa Turkoz
CANCER RESEARCHno. 7 (2023)
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Mahdi Moqri,Andrea Cipriano, Daniel Nachun,Tara Murty,Guilherme de Sena Brandine, Sajede Rasouli,Andrei Tarkhov,Karolina A. Aberg,Edwin van den Oord,Wanding Zhou,Andrew Smith,Crystal Mackall,
bioRxiv (Cold Spring Harbor Laboratory) (2022)
Andrea Cipriano,Alessio Colantoni, Danielle Gomes,Mahdi Moqri, Alexander Parker, Matthew Caldwell,Francesca Briganti,Jonathan Fiorentino,Maria Grazia Roncarolo,Antonio Baldini,Katja G Weinacht,Gian Gaetano Tartaglia,
biorxiv(2022)
Priscila Ferreira Slepicka,Kelsea M. Hubka, Hanh Dan Nguyen, Abdulvasey Mohammed,Jing Wang,Casey Gifford,Vittorio Sebastiano,Katja G. Weinacht
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