His research focuses on developing new methodology for mathematical optimization with applications to network design, scheduling, vehicle routing, data mining, health care operations, and analytical marketing. He published over 60 academic articles, and co-authored the book "Decision Diagrams for Optimization." Van Hoeve’s research has been funded by the National Science Foundation, the Office of Naval Research, and two Google Faculty Research Awards. He has consulted for a variety of companies including FedEx Ground, Exxon Mobil, PNC Bank, Bosch/Siemens, Charter Steel, Kalibrate, and others. Van Hoeve received the Tepper School's MBA Teaching Award twice, as well as the MSBA Teaching Award.