The focus of her research is on behavioral, psychosocial and family factors that affect pain experiences, the interrelationship of sleep and pain, and innovative psychological treatments for managing and preventing chronic pain. Currently, Dr. Palermo serves as Editor-in-Chief of the Journal of Pain. Dr. Palermo has developed and evaluated several internet and mobile applications to deliver cognitive-behavioral interventions for chronic pain, has published over 290 articles, and has published two books on cognitive-behavioral therapy. She is active in training clinician-scientists at the postdoctoral and faculty level and directs the T32 postdoctoral training program in anesthesiology research at the University of Washington.