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Research in the Hyster group focuses on developing new biocatalytic methods to address long-standing reactivity and selectivity challenges in organic synthesis. To this end, we are developing photoenzymatic strategies for generating organic free radicals within protein active sites. Using protein engineering and directed evolution, we can precisely control the reactivity of radical intermediates. This feature enables enzymes to address challenges in the field of organic free-radical chemistry. We are also inventing new biocompatible photoredox reactions, enabling cascade reactions involving small molecule and enzymatic catalysts. These new tools can be applied to challenges encountered by the agrochemical and pharmaceutical industries.
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论文共 96 篇作者统计合作学者相似作者
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Yi Liu,Sophie G Bender,Damien Sorigue,Daniel J Diaz,Andrew D Ellington,Greg Mann, Simon Allmendinger,Todd K Hyster
Journal of the American Chemical Societyno. 11 (2024): 7191-7197
Nature Catalysisno. 1 (2024): 35-42
Jose Carceller, Bhumika Jayee,Claire Page,Daniel Oblinsky,Nithin Chintala, Gustavo Mondragón-Solórzano,Jingzhe Cao, Zayed Alassad,Zheyu Zhang, Nathaniel White,Gregory Scholes,Sijia Dong,
crossref(2024)
Journal of the American Chemical Society (2024)
Accounts of chemical research (2024)
Yi Liu,Sophie G. Bender,Damien Sorigue,Daniel J. Diaz, Andrew D. Ellington,Greg Mann, Simon Allmendinger,Todd K. Hyster
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 11 (2024): 7191-7197
Accounts of Chemical Research (2024)
Research squareno. 21 (2023): 11866-11874
Matteo Capone, Gianluca Dell'Orletta,Bryce T. Nicholls,Gregory D. Scholes,Todd K. Hyster,Massimiliano Aschi,Isabella Daidone
ACS catalysisno. 23 (2023): 15310-15321
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