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Research in the Sanderson lab is focused on understanding brain damage caused by ischemic insults during cardiac arrest, ischemic stroke, and neonatal hypoxia/ischemia. Ongoing mechanistic studies are focused on uncovering novel pathologic mechanisms of inner mitochondrial membrane proteins involved in mitochondrial dynamics, quality control, cristae maintenance, and cell death execution. These studies utilize novel cell and small animal models of brain ischemia in transgenic mice to evaluate mitochondrial dysfunction. A second area of focus is the development and clinical translation of neuroprotective therapies that modulate the activity of mitochondria to reduce brain injury. Pre-clinical large animal studies are ongoing to evaluate a novel therapeutic strategy that limits mitochondrial hyperactivity and prevents ROS production following brain ischemia. This research has resulted in two awarded US patents, which formed the foundation of the startup company, Mitovation, Inc. Ongoing studies supported by the NIH and DoD are focused on investigating the mechanisms of this therapy through continued testing in large animals, along with regulatory testing of human therapy devices that can bring this treatment to the clinic.
Research Interests
Papers共 160 篇Author StatisticsCo-AuthorSimilar Experts
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Sanjana Chandran,Thomas H. Sanderson
Strokeno. Suppl_1 (2024)
Luis O. Correa-Medero, Shayna E. Jankowski,Hanna S. Hong, Nicholas D. Armas, Aditi I. Vijendra,Mack B. Reynolds,Garrett M. Fogo,Dominik Awad, Alexander T. Dils, Kantaro A. Inoki, Reid G. Williams, Annabelle M. Ye,Nadezhda Svezhova,Francisco Gomez-Rivera,Kathleen L. Collins,Mary X. O'Riordan,Thomas H. Sanderson,Costas A. Lyssiotis,Shannon A. Carty
Philosophical Transactions of the Royal Society B Biological Sciencesno. 1906 (2024)
Synaptic Tagging and Capturepp.43-61, (2024)
FASEB journal official publication of the Federation of American Societies for Experimental Biologyno. 18 (2024): e70066-e70066
Scientific reportsno. 1 (2024): 13081-13081
Cellsno. 6 (2024): 493
Bioengineering & translational medicineno. 3 (2023): e10496-e10496
Paul T. Morse,Gonzalo Pérez-Mejías,Junmei Wan,Alice A. Turner,Inmaculada Márquez,Hasini A. Kalpage,Asmita Vaishnav,Matthew P. Zurek, Philipp P. Huettemann,Katherine Kim,Tasnim Arroum,Miguel A. De la Rosa,Dipanwita Dutta Chowdhury,Icksoo Lee,Joseph S. Brunzelle,Thomas H. Sanderson,Moh H. Malek,David Meierhofer,Brian F. P. Edwards,Irene Díaz-Moreno,Maik Hüttemann
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Author Statistics
#Papers: 164
#Citation: 5094
H-Index: 40
G-Index: 69
Sociability: 7
Diversity: 0
Activity: 1
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