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Research in the Sanderson lab is focused on understanding brain damage caused by ischemic insults during cardiac arrest, ischemic stroke, and neonatal hypoxia/ischemia. Ongoing mechanistic studies are focused on uncovering novel pathologic mechanisms of inner mitochondrial membrane proteins involved in mitochondrial dynamics, quality control, cristae maintenance, and cell death execution. These studies utilize novel cell and small animal models of brain ischemia in transgenic mice to evaluate mitochondrial dysfunction. A second area of focus is the development and clinical translation of neuroprotective therapies that modulate the activity of mitochondria to reduce brain injury. Pre-clinical large animal studies are ongoing to evaluate a novel therapeutic strategy that limits mitochondrial hyperactivity and prevents ROS production following brain ischemia. This research has resulted in two awarded US patents, which formed the foundation of the startup company, Mitovation, Inc. Ongoing studies supported by the NIH and DoD are focused on investigating the mechanisms of this therapy through continued testing in large animals, along with regulatory testing of human therapy devices that can bring this treatment to the clinic.
Research Interests
Papers共 163 篇Author StatisticsCo-AuthorSimilar Experts
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Laura Harding,Joshua Mergos,Mohamad Tiba, Traci Cramer, Nicholas Greer,William Stacey, Claudio Sandroni,Thomas Sanderson,Robert Neumar,Cindy Hsu
Circulationno. Suppl_1 (2024)
Sanjana Chandran,Thomas H. Sanderson
Strokeno. Suppl_1 (2024)
Luis O. Correa-Medero, Shayna E. Jankowski,Hanna S. Hong, Nicholas D. Armas, Aditi I. Vijendra,Mack B. Reynolds,Garrett M. Fogo,Dominik Awad, Alexander T. Dils, Kantaro A. Inoki, Reid G. Williams, Annabelle M. Ye,Nadezhda Svezhova,Francisco Gomez-Rivera,Kathleen L. Collins,Mary X. O'Riordan,Thomas H. Sanderson,Costas A. Lyssiotis,Shannon A. Carty
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCESno. 1906 (2024)
Synaptic Tagging and Capturepp.43-61, (2024)
FASEB JOURNALno. 18 (2024)
SCIENTIFIC REPORTSno. 1 (2024)
Cellsno. 6 (2024): 493
Sarah Trimpin, Frank S Yenchick,Chuping Lee,Khoa Hoang,Milan Pophristic,Santosh Karki,Darrell D Marshall,I-Chung Lu,Corinne A Lutomski,Tarick J El-Baba,Beixi Wang,Vincent S Pagnotti,Anil K Meher, Shubhashis Chakrabarty, Lorelei F Imperial,Sara Madarshahian,Alicia L Richards,Christopher B Lietz,Abigail Moreno-Pedraza,Samantha M Leach,Stephen C Gibson,Efstathios A Elia,Shameemah M Thawoos,Daniel W Woodall,Dean R Jarois,Eric T J Davis,Guochao Liao,Nisansala S Muthunayake,McKenna J Redding,Christian A Reynolds,Thilani M Anthony,Sashiprabha M Vithanarachchi,Paul DeMent,Adeleye O Adewale, Lu Yan,James Wager-Miller,Young-Hoon Ahn,Thomas H Sanderson,Karin Przyklenk,Miriam L Greenberg,Arthur G Suits,Matthew J Allen,Srinivas B Narayan,Joseph A Caruso,Paul M Stemmer,Hien M Nguyen,Steffen M Weidner, Kevin J Rackers, Ana Djuric,Vladimir Shulaev,Tamara L Hendrickson,Christine S Chow,Mary Kay H Pflum,Scott M Grayson,Vladislav V Lobodin,Zhongwu Guo,Chi-Kung Ni,J Michael Walker,Ken Mackie,Ellen D Inutan,Charles N McEwen
Journal of the American Society for Mass Spectrometry (2024)
Woo Jin Jung,Francesca Fumagalli, Aurora Magliocca, Olof Persson,Lauge Vammen, Alexander Szinovatz, Hakam Tiba, Wolfgang Weihs, Mikulas Mlcek,Cindy Hsu,Thomas Sanderson, Asger Granfeldt, Jan Belohlavek,Michael Holzer, Renaud Tissier, Guiseppe Ristagno, Kyoung-Chul Cha,Hans Friberg,Robert Neumar
Resuscitation (2024)
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Author Statistics
#Papers: 163
#Citation: 4991
H-Index: 38
G-Index: 68
Sociability: 7
Diversity: 0
Activity: 1
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