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We aim to understand ion transport processes from the molecular to the cellular and up to the level of the organism. The latter levels are addressed with genetic mouse models and the analysis of human genetic diseases. In particular, we study CLC Cl- channels and transporters and, more recently, volume-regulated VRAC/LRRC8 and acid-activated ASOR/TMEM206 channels. Key research areas are structure/function analysis, neurobiology, extracellular signaling, volume regulation, and cell biology of the endosomal-lysosomal system. We investigate many organs, including the brain, inner ear, kidney, the immune system and endocrine organs such as the adrenal gland and endocrine pancreas. After our breakthrough in identifying the long-sought volume-regulated anion channel VRAC in 2014, we elucidate its diverse functions. Our identification of ASOR in 2019 opened yet another new area of research. Our analysis of a large collection of mouse models has provided crucial biological and medically relevant insights.
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论文共 361 篇作者统计合作学者相似作者
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Maya M. Polovitskaya, Tanushka Rana, Kurt Ullrich,Simona Murko,Tatjana Bierhals, Guido Vogt, Tobias Stauber,Christian Kubisch, René Santer,Thomas J. Jentsch
Journal of Biological Chemistrypp.107437, (2024)
Dmitry Tsvetkov,Johanna Schleifenbaum,Yibin Wang,Mario Kassmann,Maya M. Polovitskaya, Mohamed Ali, Sebastian Schuetze,Michael Rothe,Friedrich C. Luft,Thomas J. Jentsch,Maik Gollasch
HYPERTENSIONno. 3 (2024): 561-571
H. Kapell, L. Fazio, J. Dyckow,A. Cruz-Herranz, J. Campos,C. Mayer,E. d'Este,S. Schwarz, W. Mobius,C. Cordano,A. Probstel,M. Gharagozloo,
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Bing Zhang,Sensen Zhang,Maya M. Polovitskaya,Jingbo Yi,Binglu Ye, Ruochong Li, Xueying Huang,Jian Yin, Sebastian Neuens, Tom Balfroid,Julie Soblet, Daphne Vens,
Science advancesno. 41 (2023)
JOURNAL OF CELL BIOLOGYno. 6 (2023)
Heng Liu,Maya M Polovitskaya,Linlin Yang, Meiling Li, Hongyue Li,Zhen Han, Jianguo Wu,Qiansen Zhang,Thomas J Jentsch,Jun Liao
Cell reportsno. 8 (2023): 112926-112926
Hannah Kapell,Luca Fazio,Julia Dyckow, Sophia Schwarz,Andrés Cruz-Herranz,Christina Mayer,Joaquin Campos,Elisa D´Este,Wiebke Möbius,Christian Cordano,Anne-Katrin Pröbstel,Marjan Gharagozloo,
Journal of Clinical Investigationno. 7 (2023)
Shroddha Bose,Cecilia de Heus, Mary E. Kennedy, Fan Wang,Thomas J. Jentsch,Judith Klumperman,Tobias Stauber
Biomoleculesno. 12 (2023)
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