Tesfaye B. Mersha, PhD, is a quantitative geneticist. His background includes an early exposure to the many facets of biology and statistics and interested in cross-line disciplines to understand and solve complex genetic problems. During his post-doctoral fellowship program in statistical and human genetics, Dr. Mersha worked on statistical genetics methodologies and applied genetical data analysis to localize disease genes. Particularly, he focused on genetic analyses of metabolic and mental disorders using linkage, association and admixture mapping approach. He developed genome-wide ancestry informative markers (AIMs) panel by mining databases including HapMap, Affymetrix and Illumina. The AIM markers are useful in ancestry inference, admixture mapping and structured association testing. He used over 4 million HapMap SNP data and developed approaches of chromosomal based finer population genetic structure characterization, localization of private SNPs and associated genes and pathways that could have pharmacogenomics implication. In addition, Dr. Mersha is working on gene regulatory networks, gene ontology enrichment analysis and molecular profiling using various biologic and bioinformatic methodology for prioritizing asthma candidate genes. Dr. Mersha’s overall research interest and goal includes the use of population genomics, quantitative genetics, statistical genetics as well as proteomics and biological profiling and pathway methods to understand and dissect common complex diseases.