基本信息
浏览量:50
职业迁徙
个人简介
Disciplines
Biology
Topic
Biotechnology
Microbiology
Neuroscience
Virology
Developmental Biology
Medicine
Topic
Oncology
Clinical Immunology
Cancer progression is driven in part by the mutation of genes that mediate immortality, angiogenesis, metastasis, changes in energy metabolism, and evasion of the immune system. P53 mutation is one of the most common genetic changes in cancer development that leads to a re-wiring and selective survival advantage to the developing cancer cell. This genetic re-wiring involves changes in the transciptome, the proteome, and the phenotype of the cell within a specific microenvironmental niche in vivo. The lab is using biophysical, biochemical, and proteomic approaches to develop novel molecular insights into clinically relevant cancer progression pathways; particularly cancers of unmet clinical need including oesophageal adenocarcinoma and sarcomas. Emerging therapeutic strategies being developed include drugging protein-protein interactions; biologics and immunotherapeutics; and proteogenomics platforms that define mutated neoantigen landscapes to facilitate cancer vaccine developments.
研究兴趣
论文共 330 篇作者统计合作学者相似作者
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Cancer Researchno. 6_Supplement (2024): 74-74
Mass spectrometry reviews (2024)
Marta Nekulova, Marta Wyszkowska, Nela Friedlova,Lukas Uhrik,Filip Zavadil Kokas,Vaclav Hrabal,Lenka Hernychova,Borivoj Vojtesek,Ted R. Hupp,Michal R. Szymanski
Biological Chemistryno. 0 (2024)
Alison Daniels,Monikaben Padariya,Sarah Fletcher,Kathryn Ball,Ashita Singh,Neil Carragher,Ted Hupp, Christine Tait-Burkard,Umesh Kalathiya
Antiviral Research (2024): 105949-105949
Communications biologyno. 1 (2024): 708-708
Lucia Martinkova,Pavlina Zatloukalova,Martina Kucerikova, Nela Friedlova, Zuzana Tylichova,Filip Zavadil-Kokas,Ted Robert Hupp,Philip John Coates,Borivoj Vojtesek
Cellular & Molecular Biology Lettersno. 1 (2024)
Frontiers in genetics (2024): 1407375-1407375
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作者统计
#Papers: 331
#Citation: 12108
H-Index: 53
G-Index: 100
Sociability: 7
Diversity: 4
Activity: 88
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