Research Interests Nuclear receptor PPAR in health and diseases Phytochemicals as therapeutic targets of metabolic diseases Transgenic animals for disease models Representative Publications Ko JK, Lee SST, Martin H: Phytochemicals as modulators of PPARs and RXRs. PPAR Res 2010, 2010:1-2. Zhao Q, Chan YW, Lee SST, Cheung WT: One-step expression and purification of single-chain variable antibody fragment using an improved hexahistidine tag phagemid vector. Protein Expr Purif 2009,68:190-195. Sun Y, Ng L, Lam W, Lo CKC, Chan PT, Yuen YL, Wong PF, Tsang DSC, Cheung WT, Lee SST: Identification and characterization of a novel mouse peroxisome proliferator-activated receptor α-regulated and starvation-induced gene, Ppsig. Int J Biochem Cell Biol 2008, 40:1775-1791. Avasarala S, Yang L, Sun Y, Leung WC, Chan WY, Cheung WT, Lee SST: A temporal study on the histological, biochemical and molecular responses of CCl4-induced hepatotoxicity in Cyp2e1-null mice.Toxicology 2006,228:310-322. Lee SST, Chan WY, Lo CKC, Wan CC, Tsang SC, Cheung WT: Requirement of PPARα in maintaining phospholipid and triacylglycerol homeostasis during energy deprivation.J Lipid Res 2004,45:2025-2037. Lee SST, Tian L, Lee WS, Cheung WT: Application of fluorescent differential display and peroxisome proliferator-activated receptor (PPAR)α-null mice to analyze PPAR target genes.Methods Enzymol 2002, 357:214-240. Peters JM, Lee SST, Li W, Ward JM, Gavrilova O, Everett C, Reitman ML, Hudson LD, Gonzalez FJ: Growth, adipose, brain and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor β (d). Mol Cell Biol 2000,20:5119-5128. Wong FWY, Chan WY, Lee SST: Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression.Toxicol Appl Pharmacol 1998, 153:109-118. Lee SST, Buters JTM, Pineau T, Fernandez-Salguero PM, Gonzalez FJ: Role of CYP2E1 in the hepatotoxicity of acetaminophen. J. Biol Chem 1996,271:12063-12067. Lee SST, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ: Targeted disruption of the alpha-isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.Mol Cell Biol 1995, 15:3012-3022.