Dr. Manzi is recognized internationally as a pioneer in the investigation of premature cardiovascular disease in systemic lupus erythematosus and in the discovery of biomarkers for lupus diagnosis, monitoring and stratification. She has published over 250 scientific reports and book chapters and is inventor of the cell-bound complement activation products (CB- CAPs) technology platform for which she holds more than 20 patents. Her research program has received multi-million dollar support from many organizations including the NIH, the Department of Defense, the Lupus Foundation of America and the Arthritis Foundation.