Research focus
Paediatric neuromuscular disorders: Dr Chan‘s team focuses on the study of rare neuromuscular diseases from genetic diagnosis, epidemiology to clinical outcome and impact from early treatment. She has established the Neuromuscular Disorder Patient Registries. On the translational research aspects her team focuses on the use of patient-derived induced pluripotent stem cells differentiated to the affected target tissues as disease model to study the underlying disease pathogenesis and potential gene editing treatment. She is also currently the principal investigator the clinical trials of spinal muscular atrophy and Duchenne muscular dystrophy in HK
Paediatric immune-mediated neurological disorders: Dr Chan and the team diagnosed the first paediatric anti-NMDAR encephalitis in HK. Few years later, Dr Chan with Dr Ho and the team had reported a territory wide study on a local case series of paediatric patients with the anti-NMDAR encephalitis in HK showing that aggressive immunomodulating therapies in this group of patients led to a good neurological outcome. Beside autoimmune mediated encephalitis, she and her team is also studying the epidemiology and clinical outcome of patients with acquired peripheral neuropathies.