Sofia Lizarraga - Howard Hughes Medical Institute, Carnegie Institute of Washington

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Bio

We are interested in understanding the mechanisms that underlie the development of the brain and in particular the structural development of neuronal connectivity. Using a combination of genome edited and patient derived induced pluripotent stem cells (iPSC) we are focusing on eadosomal signaling mechanisms and chromatin regulatory mechanisms and how they modulate neuronal arborization http://www.lizarragalaboratory.org/

Research Interests

Papers共 34 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

Neuroimmune mechanisms in autism etiology - untangling a complex problem using human cellular models

Janay M Vacharasin,Joseph A Ward,Mikayla M McCord, Kaitlin Cox,Jaime Imitola,Sofia B Lizarraga

Oxford open neuroscience (2024): kvae003-kvae003

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The Role of Histone Methyltransferases in Neurocognitive Disorders Associated with Brain Size Abnormalities

Foster D. Ritchie,Sofia B. Lizarraga

FRONTIERS IN NEUROSCIENCE (2023)

Cited1Views0Bibtex

Interferome perturbation of human brain organoids induces progenitor and neuronal dysfunction seen in multiple sclerosis and autism

Ethan Hollingsworth,Dominic Julian,Fumihiro Watanabe,Trevor Reutershan, Katie Julian, Ivette Martorell Serra,Sofia Lizarraga,Mark Hester,Jaime Imitola

NEUROLOGYno. 17 (2023)

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The Warburg Micro Syndrome Protein RAB3GAP1 Modulates Neuronal Morphogenesis and Interacts with Axon Elongation End ER-Golgi Trafficking Factors

Pankaj S Ghate,Janay M Vacharasin,Joseph A Ward,Duncan Nowling,Valerie Kay,Mara H Cowen, Mary-Kate Lawlor,Mikayla McCord, Hailey Xu,Esteban Carmona,Seon-Hye Cheon,Evelyn Chukwurah,Mike Walla,Sofia B Lizarraga

Neurobiology of disease (2023): 106215-106215

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Dysregulation of the Chromatin Environment Leads to Differential Alternative Splicing As a Mechanism of Disease in a Human Model of Autism Spectrum Disorder

Calvin S. Leung,Shoshana J. Rosenzweig,Brian Yoon,Nicholas A. Marinelli,Ethan W. Hollingsworth,Abbie M. Maguire,Mara H. Cowen,Michael Schmidt,Jaime Imitola,Ece D. Gamsiz Uzun,Sofia B. Lizarraga

HUMAN MOLECULAR GENETICS（2023）

Cited1Views0WOSBibtex

Counteracting Epigenetic Mechanisms Regulate the Structural Development of Neuronal Circuitry in Human Neurons

Seonhye Cheon,Allison M. Culver,Anna M. Bagnell,Foster D. Ritchie,Janay M. Vacharasin,Mikayla M. McCord,Carin M. Papendorp,Evelyn Chukwurah,Austin J. Smith,Mara H. Cowen,Trevor A. Moreland,Pankaj S. Ghate,Shannon W. Davis,Judy S. Liu,Sofia B. Lizarraga

Molecular psychiatry（2022）

Cited5Views0WOSNATUREBibtex

Overcoming the Effect of ASH1L Haploinsufficiency on Stem Cells Amenability to Genome Editing and Differentiation into the Neuronal Lineage – a Technical Report

Se-Hyeon Cheon,Foster D. Ritchie,Janay M. Vacharasin,Nicholas A Marinelli, Collin Cheatle,Mikayla McCord, Kaitlin Cox,Sofia B. Lizarraga

bioRxiv (Cold Spring Harbor Laboratory) (2021)

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ASH1L REGULATES THE STRUCTURAL DEVELOPMENT OF NEURONAL CIRCUITRY BY MODULATING BDNF/TrkB SIGNALING IN HUMAN NEURONS

Seon Hye Cheon,Allison M. Culver,Anna M. Bagnell,Foster D. Ritchie,Janay M. Clytus,Mikayla McCord,Carin M. Papendorp,Evelyn Chukwurah,Austin J. Smith,Mara H. Cowen,Pankaj S. Ghate,Shannon W. Davis,Judy S. Liu,Sofia B. Lizarraga

biorxiv（2020）

Cited1Views0Bibtex

Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly

B. Celia Cui,Vitali Sikirzhytski,Marina Aksenova,Matthew D. Lucius, Gabrielle H. Levon,Zachary T. Mack, Charlotte Pollack,Diana Odhiambo,Eugenia Broude,Sofia B. Lizarraga,Michael D. Wyatt,Michael Shtutman

BIOCHEMICAL PHARMACOLOGY（2020）

Cited15Views0WOSBibtex

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