基本信息
浏览量:305
职业迁徙
个人简介
My group’s research interests focus on the area of population genetics, specifically the use of stochastic models to understand patterns of variation in samples drawn from a population. Work is also ongoing on methods to map disease genes in admixed populations, and methods for fine-mapping association signals. I spend part of my time in the Department of Statistics, and part of my time at the Wellcome Trust Centre for Human Genetics (WTCHG).
For a number of years I have worked on studying patterns of recombination in different species, currently including humans, chimpanzees and mice, and this continues to be a strong theme of the group. I developed methods to detect such hotspots from genetic data, based on using the coalescent with recombination as a model for the population genealogy. The key achievements of this work have been in demonstrating that recombination occurs very unevenly throughout the human genome, with most recombination occurring in narrow hotspots in both sexes, and that most hotspots have a short lifespan and are not shared with chimpanzee. In the last three years, this work has further led directly on to the identification of the first sequence motifs that are associated with hotspot activity in humans, evidence that these same motifs mark sites of recurrent disease-causing genomic rearrangements in humans, and the identification of a gene, PRDM9, binding one of these motifs. Currently, my group is actively continuing this research, using both population genetics based and experimental approaches.
For a number of years I have worked on studying patterns of recombination in different species, currently including humans, chimpanzees and mice, and this continues to be a strong theme of the group. I developed methods to detect such hotspots from genetic data, based on using the coalescent with recombination as a model for the population genealogy. The key achievements of this work have been in demonstrating that recombination occurs very unevenly throughout the human genome, with most recombination occurring in narrow hotspots in both sexes, and that most hotspots have a short lifespan and are not shared with chimpanzee. In the last three years, this work has further led directly on to the identification of the first sequence motifs that are associated with hotspot activity in humans, evidence that these same motifs mark sites of recurrent disease-causing genomic rearrangements in humans, and the identification of a gene, PRDM9, binding one of these motifs. Currently, my group is actively continuing this research, using both population genetics based and experimental approaches.
研究兴趣
论文共 180 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
PHOTOCHEMISTRY AND PHOTOBIOLOGYno. 1 (2024): 115-128
NATURE GENETICS (2024)
Sinan Shi,Simone Rubinacci,Sile Hu,Loukas Moutsianas,Alex Stuckey,Anna C Need, The Genomics England Research Consortium,Mark Caulfield,Jonathan Marchini,Simon Myers
medrxiv(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Elsevier eBookspp.491-532, (2023)
Sile Hu, Liliana Harumi Kuabara Ferreira,Sinan Shi,Garrett Hellenthal,Jonathan Marchini,Daniel J. Lawson,Simon Myers
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Justine Victoria Sullivan,Simon Myers
Plastic Surgery - Principles and Practicepp.1-14, (2022)
加载更多
作者统计
#Papers: 180
#Citation: 17972
H-Index: 48
G-Index: 134
Sociability: 7
Diversity: 0
Activity: 1
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn