I have developed novel prophylactic and/or therapeutic tools against infections by T. cruzi and Leishmania spp. I have worked on the cloning and expression of different relevant antigens of the aforementioned parasites for their use in experimental prophylactic and/or therapeutic vaccines against Chagas disease and Leishmaniasis. We go deeper into the immunomodulatory properties of these antigens on dendritic cells and macrophages and their role in the immunomodulation exerted by the parasite in Chagas disease. At the same time, I worked on the identification of effective natural and synthetic products against Leishmania spp. and T. cruzi, which could provide the basis for the development of new therapeutic tools. I recently began the study of the immunological mechanisms that probiotic lactic acid bacteria trigger at the level of the intestinal mucosa. Specifically, the role of probiotic bacteria in the production of antimicrobial peptides produced by Paneth cells and the reinforcing the intestinal barrier, in normal conditions and in intestinal inflammation disorders.