In his own lab, Dr. Krishnakumar aims to delineate the molecular mechanisms of synchronicity and use-dependent plasticity of neurotransmitter release and how it is altered in paroxysmal movement disorders. The balance between different modes of neurotransmitter release and short-term plasticity plays an important role in coordinating activity within neuronal networks and provides a basis for synaptic computation. Any alterations that affect the timing or probability of release result in a wide range of neurological disorders. To this end, he employs multidisciplinary biochemical, biophysical, and structural methods, with a specific focus on systematic biochemical reconstitution strategies.