Dr. Kelsey's research interests are in the coordination of multicenter clinical trials and registries primarily in cardiology, but also in diabetes, women's health, neurology, and ophthalmology. She has served as Principal Investigator for coordinating centers for a number of National Institutes of Health-sponsored multicenter clinical trials and registries. She has served on over thirty Data and Safety Monitoring Boards for the National Institutes of Health, the Veteran's Administration and industry.