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Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide. The high death rates in CRC as well as other solid tumours are mainly due to metastatic dissemination of cancer cells to distant organ sites. It is estimated that 50%–60% of patients diagnosed with CRC will develop metastasis. Metastasis is a complex multistep process that requires cells from the primary tumour to exhibit remarkable phenotypic plasticity at distant metastatic microenvironments for successful outgrowth. The understanding of underlying biological mechanisms involved in this metastatic transition is essential to identify critical nodes for clinical intervention to halt the disease in its progression. I am interested in investigating how the metastatic niche influences secondary tumor outgrowth by inducing cancer-promoting functions, such as proliferation, ECM remodeling, migration, invasion and angiogenesis.
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论文共 20 篇作者统计合作学者相似作者
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Eoghan J Mulholland,Hayley L Belnoue-Davis,Gabriel N Valbuena,Nuray Gunduz, Amelia Ligeza,Sujata Biswas, Ester Gil Vasquez, Sulochana Omwenga,Nadia Nasreddin,Michael Hodder,Lai Mun Wang,Shazia Irshad,
crossref(2024)
ONCOGENEno. 10 (2023): 782-782
William Dalleywater, Alexander V Predeus, Batuhan Cakir, Pavel Mazin,Jayakumar Vadakekolathu,Sergio Rutella, Marian L Meakin,Alison A Ritchie, Shamir Montazid,Sara Cuevas Ocaña,Nadine Holmes,Victoria Wright,
biorxiv(2023)
Shamir Montazid,Sheila Bandyopadhyay,Daniel W. Hart,Nan Gao,Brian Johnson, Sri G. Thrumurthy, Dustin J. Penn, Bettina Wernisch,Mukesh Bansal,Philipp M. Altrock,Fabian Rost, Patrycja Gazinska,
Nature Communicationsno. 1 (2023): 1-20
The Journal of Pathology (2017)
JOURNAL OF BIOLOGICAL CHEMISTRYno. 2 (2015): 888-888
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