Shariff Bayoumy - Mebias Discovery | 人才画像

基本信息

Career Trajectory

Bio

Shariff Bayoumy is a Managing Partner and co-founder of Mebias Discovery. Shariff is involved in drug discovery with a focus on discovery and development of bias ligands to GPCRs. His most recent publication is 'Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.'

Research Interests

Papers共 15 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

Novel, Highly Biased Mu Opioid Receptor Compounds Minus Side Effects for the Treatment of Pain

B. Tounge,S. Bayoumy, R. Besthof,S. Dax,L. Kuo, J. Barrett

Journal of Pain（2018）

Cited0Views0Bibtex

A novel fluorogenic substrate for the measurement of endothelial lipase activity

Andrew L Darrow,Matthew W Olson,Hong Xin,Sharon L Burke,Charles Smith,Celine Schalk-Hihi,Robyn Williams,Shariff S Bayoumy,Ingrid C Deckman,Matthew J Todd,Bruce P Damiano,Margery A Connelly

Journal of Lipid Research（2011）

Cited25Views0WOSBibtex

Potency Variation of Small-Molecule Chymase Inhibitors Across Species

Jukka Kervinen,Carl Crysler,Shariff Bayoumy,Marta C. Abad,John Spurlino,Ingrid Deckman,Michael N. Greco,Bruce E. Maryanoff,Lawrence de Garavilla

Biochemical Pharmacology（2010）

Cited25Views0WOSBibtex

X-ray structure of human chymase in complex with small molecule inhibitor

M.C. Abad,J. Kervinen,C. Crysler,S. Bayoumy,J. Spurlino,I. Deckman,M.N. Greco,B.E. Maryanoff, L. Degaravilla

crossref（2010）

Cited0Views0Bibtex

Structural Basis for Elastolytic Substrate Specificity in Rodent Α-Chymases

Jukka Kervinen,Marta Abad,Carl Crysler,Michael Kolpak,Andrew D. Mahan,John A. Masucci,Shariff Bayoumy,Maxwell D. Cummings,Xiang Yao,Matthew Olson,Lawrence de Garavilla,Lawrence Kuo,Ingrid Deckman,John Spurlino

Journal of Biological Chemistry（2007）

Cited18Views0WOSBibtex

Protein Engineering of the Colony-stimulating Factor-1 Receptor Kinase Domain for Structural Studies

Celine Schalk-Hihi,Hong-Chang Ma,Geoffrey T. Struble,Shariff Bayoumy,Robyn Williams,Eric Devine,Ioanna P. Petrounia,Tara Mezzasalma,Lee Zeng,Carsten Schubert,Bruce Grasberger,Barry A. Springer,Ingrid C. Deckman

Journal of biological chemistry/The Journal of biological chemistry（2007）

Cited12Views0WOSBibtex

Effect of Construct Design on MAPKAP Kinase-2 Activity, Thermodynamic Stability and Ligand-Binding Affinity

J Kervinen,HC Ma,S Bayoumy,C Schubert,C Milligan,F Lewandowski, K Moriarty, RL DesJarlais, K Ramachandren, HY Wang, CA HarriS,B Grasberger,M Todd,BA Springer,I Deckman

Archives of biochemistry and biophysicsno. 1-2 (2006): 47-56

Cited18Views0WOSBibtex

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