The Samarajiwa lab studies gene and epigenome regulatory processes that contribute to normal physiology and disease pathology. This includes the regulation of host defence responses (antiviral, inflammatory, anti-tumour responses), ageing, immune & inflammatory diseases and carcinogenesis.
Perturbation of the cellular information flow due to mutations, genetic aberrations, ploidy, metabolic reprogramming and cellular pathway and network deregulation, results in complex phenotypes that promote disease states. The Samarajiwa lab integratively studies gene (transcriptome and translatome), epigenome and chromatin architecture regulation affecting these processes and phenotypes at the systems level.