基本信息
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Bio
We are using protein x-ray crystallography to study a number of systems including: phosphatases, including exopoly and pyrophosphatases; aldoketoreductases and nitroreductases, enzymes targetted in anticancer therapies, and DNA-binding proteins. In each case we are determining structures of wild-type and engineered mutant enzymes, in the absence or presence of bound ligands, inhibitors or substrate analogues, in order to gain insight into protein function or further structure-based drug design.
Research Interests
Papers共 74 篇Author StatisticsCo-AuthorSimilar Experts
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Proteins: Structure, Function, and Bioinformaticsno. 5 (2022): 585-592
Angewandte Chemieno. 46 (2021): 24678-24682
crossref(2019)
Mohammed Jamshad, Timothy J. Knowles,Scott A. White,Douglas G. Ward,Fiyaz Mohammed, Kazi Rahman,Gareth W. Hughes,Günter Kramer,Bernd Bukau,Damon Huber
crossref(2018)
Deborah J Eaves,Tamanna Haque, Richard L Tudor,Yoshimi Barron,Cleidiane G Zampronio, Nicholas P J Cotton,Barend H J de Graaf,Scott A White,Helen J Cooper,F Christopher H Franklin,Jeffery F Harper,Vernonica E Franklin-Tong
Plant physiologyno. 3 (2017): 1606-1616
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Author Statistics
#Papers: 77
#Citation: 2593
H-Index: 29
G-Index: 50
Sociability: 6
Diversity: 3
Activity: 10
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