She has played a major role as a statistician in the establishment, conduct and interpretation of CTSU’s series of ground-breaking large-scale randomised trials in the treatment and prevention of cardiovascular disease. She has also been active in developing large-scale blood-based observational studies with extensive biomarker panels and genotyping. As the Director of Statistics in Vascular Trials and Genetic Epidemiology, she now leads statistical teams engaged in a spectrum of complimentary research. Her particular interests include: identifying genetic risk factors for the side-effects of common cardiovascular treatments; investigating causality in relation to factors such as adiposity and dementia that are responsible for major burdens of disease, using the large UK and China Kadoorie biobanks.