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个人简介
My clinical practice is focused on inflammatory and allergic gastrointestinal disorders. In particular, I am interested in the role of food and environmental allergies in chronic abdominal pain and inflammatory bowel disease.
My bench research focuses on innate immune mechanisms in gut inflammation.
Currently, there are two distinct projects going on in my lab. The first project focuses on the role of innate lymphoid cells play in mucosal healing and disease in IBD.
The second project focuses on the role environmental antigens play in chronic antigen mediated GI diseases such as eosinophilic esophagitis and GI mast cell disorders. The in vitro data done in your lab to date shows that environmental antigens such as ragweed and dust mites lead to disruption of tight junctions in the presence of eosinophils and mast cells via their influence on TSLP.
My R-O1 ended in 2013. It focused on how the mechanical features underlying malignant cells at the luminal interface influence tumor spread. The theory behind this project was that under normal circumstances cells in the colon, including colonic stem cells, follow a strict mechanical axis wherein they migrate from the bottom of the crypt to the top. In the setting of cancer, the axis is distorted and cells are permitted to move in both a two- and three-dimensional fashion. As such, significant changes occur in the topography underlying cells on the luminal side of a tumor.
Overall, both my clinical and research interests are focused on understanding the role of gut microenvironment in both non-neoplastic and neoplastic gastrointestinal disorders.
研究兴趣
论文共 207 篇作者统计合作学者相似作者
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Alexander Abadir, Angela Troia,Hyder Said,Spurthi Tarugu,Benjamin C. Billingsley, Nathan Sairam,Scott B. Minchenberg,Anna H. Owings,Adam M. Parker,Brandon Brousse,Alexander Carlyle, Bobby R. Owens,Pegah Hosseini-Carroll,Michelle Galeas-Pena, Joseph Frasca,Sarah C. Glover,Konstantinos Papamichael,Adam S. Cheifetz
Digestive Diseases and Sciencespp.1-8, (2024)
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crossref(2024)
Mariana Castells,Matthew P Giannetti,Matthew J Hamilton,Peter Novak,Olga Pozdnyakova,Jennifer Nicoloro-SantaBarbara,Susan V Jennings,Clair Francomano,Brian Kim,Sarah C Glover,Stephen J Galli,Anne Maitland,Andrew White,J Pablo Abonia,Valerie Slee,Peter Valent,Joseph H Butterfield,Melody Carter,Dean D Metcalfe,Cem Akin,Jonathan J Lyons,Alkis Togias,Lisa Wheatley,Joshua D Milner
The Journal of allergy and clinical immunologyno. 2 (2024): 255-263
The American journal of the medical sciencesno. 6 (2023): 488-495
GASTROENTEROLOGYno. 6 (2023): S134-S135
International journal of molecular sciencesno. 2 (2023): 1654-1654
medRxiv the preprint server for health sciences (2023)
Jack Chovanec,Ilker Tunc,Jason Hughes,Joseph Halstead,Allyson Mateja,Yihui Liu,Michael P O'Connell,Jiwon Kim,Young Hwan Park,Qinlu Wang,Quang Le,Mehdi Pirooznia,Neil N Trivedi,Yun Bai,Yuzhi Yin,Amy P Hsu,Joshua McElwee,Sheryce Lassiter,Celeste Nelson,Judy Bandoh,Thomas DiMaggio,Julij Šelb,Matija Rijavec,Melody C Carter,Hirsh D Komarow,Vito Sabato,Joshua Steinberg,Kurt M Hafer,Elizabeth Feuille,Christopher S Hourigan,Justin Lack,Paneez Khoury,Irina Maric,Roberta Zanotti,Patrizia Bonadonna,Lawrence B Schwartz,Joshua D Milner,Sarah C Glover,Didier G Ebo,Peter Korošec,George H Caughey,Erica H Brittain,Ben Busby,Dean D Metcalfe,Jonathan J Lyons
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作者统计
#Papers: 205
#Citation: 2715
H-Index: 25
G-Index: 50
Sociability: 7
Diversity: 0
Activity: 2
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