Russell Gotschall - M6P Therapeut, R&D

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论文共 65 篇作者统计合作学者相似作者

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Hyperactive GlcNAc-1-Phosphotransferase (S1S3 PTase) Dramatically Alters Glycosylation of Lysosomal Enzymes Leading to Enhanced Phosphorylation for Improved CI-MPR Binding and Cellular Uptake

Kylie Gray,Riley Marcinczyk,Jonathan Roberts, Uday Wanninayake,Vaughn Weaver,Michael DiGruccio,Shou Liu,Nastry Brignol,Osman Sheikh, Steven Ortemier,Clarissa Booth, Kathrine White,Russell Gotschall

GLYCOBIOLOGYno. 11 (2023): 1074-1074

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Highly phosphorylated β-glucocerebrosidase (M011) has much broader tissue targeting and superior substrate reduction with potential for alternative dosing strategies for the treatment of Gaucher disease type I

Hung Do,Kylie Gray,Michael DiGruccio,Riley Marcinczyk,Udayanga Wanninayake, Susan Abdel-Rahman, Lin Liu,Russell Gotschall

Molecular Genetics and Metabolism（2023）

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Highly Phosphorylated Β-Glucocerebrosidase (M011) That Targets Central Nervous System Neurons As a Potential Treatment for Neuronopathic Gaucher Disease Type 2 and 3

Michael DiGruccio,Steven B. Ortmeier,Udayanga Wanninayake,Jonathan Roberts, Lin Liu,Russell Gotschall,Hung Do

Molecular genetics and metabolismno. 2 (2023): 107079-107079

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M021: rhGAA with optimal glycosylation profile containing very high levels of bis-phosphorylated N-glycans clears accumulated glycogen and rapidly normalizes muscle strength in treated Pompe disease mice

Russell Gotschall,Michael DiGruccio,Kylie Gray,Linda Lyons,Riley Marcinczyk,Jonathan Roberts,Udayanga Wanninayake,Vaughn Weaver,Lydia R. Gotschall,Clarissa Booth, Rebecca Moser,Steven B. Ortmeier,Katherine White, Benjamin Forred, Lin Liu,Hung Do

Molecular Genetics and Metabolismno. 2 (2023): 107125-107125

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M021: A Uniquely Glycosylated, Highly Phosphorylated Acid-Alpha Glucosidase Enzyme Replacement Therapy for the Treatment of Pompe Disease

Russell Gotschall, Lin Liu,Kylie Gray,Nick Wessler,Aaron Brown,Vaughn Weaver,Linda Lyons, Heather Clark,Jonathan Roberts,Michael DiGruccio,Hung Do

Molecular genetics and metabolism（2022）

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M021: Pompe Enzyme Replacement Therapy with Highly Phosphorylated Oligosaccharides by the Co-Expression of Acid Alpha-Glucosidase with S1S3 GlcNAc-1-Phosphotransferase

Russell Gotschall,Jonathan Roberts,Kylie Gray,Linda Lyons, Riley Marcincyk,Udayanga Wanninayake, Annie Arnold,Lydia Gotschall,Vaughn Weaver,Peng Zhao,Lance Wells,Lin Liu,Hung Do,Michael DiGruccio

GLYCOBIOLOGYno. 11 (2022)

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A Novel S1S3 Phosphotransferase Co-Expression Gene Therapy Platform for Lysosomal Disorders

Andrew C. Hedman, Nathan Swyers,Jennifer Srnak,Yicheng Zhao,Russell Gotschall, Lin Liu

Molecular genetics and metabolism（2022）

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M011: A novel highly phosphorylated beta-glucocerebrosidase enzyme with broader tissue biodistribution for the treatment of Gaucher disease

Russell Gotschall, Lin Liu,Michael DiGruccio,Udayanga Wanninayake,Kylie Gray,Aaron Brown,Nick Wessler,Linda Lyons,Riley Marcinczyk, Jeremie Ferey,Hung Do

MOLECULAR GENETICS AND METABOLISM（2022）

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Co-expression of S1S3 Phosphotransferase in Production Cell Line Improves Mannose 6-Phosphorylation and Cellular Uptake of Alpha--acetylglucosaminidase (sanfilippo Syndrome Type B)

Patricia I. Dickson,Steven Q. Le,Alexander Sorensen,Balraj Doray,Shou Liu,Yicheng Zhao,Russell Gotschall,Stuart Kornfeld,Lin Liu

Molecular genetics and metabolism（2022）

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