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They were still interested in novel endothelial genes but focussed on finding those that had potential as targets in tumour vessels. This led to the discovery of C-type lectin 14A (CLEC14A). CLEC14A expression is regulated by shear stress. Low shear stress induces expression and this leads to significantly higher expression in tumour vessels (due to poor blood flow) than in those in healthy tissues. Our work on CLEC14A has taken two paths. The first is to understand its function and the second is to develop it as a target. It is clearly involved in angiogenesis and we recently characterised the interaction with its ligand multimerin-2 (MMRN2) and showed that it forms a 'supercomplex' in which multimerin2 also binds the related endosialin and CD93. We plan now to study the functional consequences and interactions of this complex. For targeting they work with Steve Lee on CAR modified T cells (funded by the cell therapy catapult) and with several companies on antibody drug conjugates. Our final interest is in developing vaccines that target the tumour vasculature.
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Papers共 281 篇Author StatisticsCo-AuthorSimilar Experts
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Joanne O’Rourke,Daniel Patten,Dean Kavanagh,Catherine E. Willoughby,Tahir Shah, Yuk Ting,Owen Cain,Derek A. Mann,Roy Bicknell,Shishir Shetty
Journal of hepatology (2024): S425-S425
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Author Statistics
#Papers: 278
#Citation: 19111
H-Index: 76
G-Index: 133
Sociability: 7
Diversity: 3
Activity: 26
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