My focus is in the treatment and long term outcomes of children treated for cancer. My specific focus is in quantifying what complications are seen in survivors of childhood cancer. Specifically, I am interested in trying to identify genetic markers that may identify those who are at risk of a specific complication. We are currently in the process of identifying genes that may explain why 20-50% of children receiving cisplatin have irreversible hearing loss. We have established a database of all adverse events in children treated through the oncology department at BC Children's Hospital. I am also interested in using linked databases to look at hospital utilization in long term survivors. Finally, I am interested in developing clinical trials in pediatric oncology both locally, as well as through the Children's Oncology Group (COG).