His research lab centers on creating and applying bulk and single cell molecular methods to generate highly resolved data using genomics technology for variant discovery and annotation. This research integrates single molecular and cellular genomics data with assays to assess chromatin accessibility, proteomics, and epigenetics data to decipher factors of pathogenesis versus normal cellular functions. Determining which cellular niches and mechanisms in complex primary tissues drive disease or resilience facilitates translation of functional genomics data using model systems for screening possible downstream regenerative and therapeutic potential using high throughput methods.
Ongoing research interests include:
Developing novel molecular methods and genome sequencing technologies
Advancing high-throughput functional genomics
Exploring whole genome and repeat content characterization for disease association
Analyzing surveillance and genomic characterization of pathogen transmission
Using genomics to temporally characterize development and pathogenesis
Translating genomic data in various oncologic diseases including gynecologic and breast cancers