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Sensory Neurons
The nervous system inputs sensory information, processes that information, and executes actions, so we can interact with the world around us. Several specialized attributes of sensory neurons enable input of information about our surroundings: these neurons have distinctive nerve endings that are in close contact with the external environment, their axons traverse great distances and they are able to transmit information rapidly and unidirectionally. Much of our research focuses on the largest set of primary sensory neurons, the dorsal root ganglia (DRG) neurons that innervate the skin and transmit sensations of touch, pain, temperature and motion.
• How is gene expression regulated in distinct intracellular sites within large sensory neurons?
Sensory neurons traverse long distances. However it is not known how proteins are differentially localized within distinct intracellular domains of sensory neurons, so that peripheral axons can initiate tactile sensation and central axons can form synapses in the spinal cord. Recent studies have highlighted the importance of mRNA transport and localized protein synthesis in spatial regulation of gene expression. We have identified mRNAs that are localized and translated in the peripheral axons of sensory neurons. We are addressing how RNA binding proteins orchestrate mRNA trafficking and protein expression within peripheral terminals and so enable tactile sensation.
• How do long peripheral axons withstand damage so they are maintained throughout life?
We identified the bcl2 family member bclw as an anti-apoptotic component highly expressed in axons of sensory neurons, and we demonstrated that loss of bclw results in progressive, sensory neuropathy due to axonal degeneration. Current studies to define mechanisms that regulate bclw expression, and to determine how bclw exerts its distinctive ability to promote axon viability and prevent axon degeneration may lead to new therapeutic approaches for degenerative disorders that impact sensory neurons.
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Sophia X. Tang, Christina M. Camara, Joy A. Franco,Maria F. Pazyra-Murphy,Yihang Li,Marina Godes, Benjamin M. Moyer, Gregory H. Bird,Rosalind A. Segal,Loren D. Walensky
Cell Chemical Biology (2024)
Grace H. Hwang,Maria F. Pazyra‐Murphy,Hyuk-Soo Seo,Sirano Dhe‐Paganon, Sylwia A. Stopka, Marina DiPiazza, Nizhoni Sutter,Thomas W. Gero, Angela Volkert, Lincoln Ombelets, Georgia Dittemore,Matthew G. Rees,Melissa M. Ronan,Jennifer A. Roth,Nathalie Y.R. Agar,David A. Scott,Rosalind A. Segal
openalex(2024)
Gustavo Alencastro Veiga Cruzeiro, Costanza Lo Cascio,Sina Neyazi, Carlos Alberto Oliveira de Biagi, Roland Haase, Andrezza Nascimento, Stephen C. Frederico, Katharina Sarnow,Varun Venkataramani,Ilon Liu, Kun Huang, Xin Tang,Rosalind A. Segal,Michelle Monje,Mariella G. Filbin
Neuro-oncologyno. Supplement_4 (2024): 0-0
Grace H. Hwang,Maria F. Pazyra-Murphy,Hyuk-Soo Seo,Sirano Dhe-Paganon, Sylwia A. Stopka, Marina DiPiazza, Nizhoni Sutter,Thomas W. Gero, Alison Volkert, Lincoln Ombelets, Georgia Dittemore,Matthew G. Rees,Melissa M. Ronan,Jennifer A. Roth,Nathalie Y.R. Agar,David A. Scott,Rosalind A. Segal
crossref(2024)
Chelsey J LeBlang,Maria F Pazyra-Murphy,Elizabeth S Silagi, Srestha Dasgupta, Marianna Tsolias, Toussaint Miller, Veselina Petrova, Shannon Zhen,Vukasin Jovanovic,David Castellano, Kathryn Gerrish,Pinar Ormanoglu,Carlos Tristan, Ilyas Singeç,Clifford J Woolf,Ozge Tasdemir-Yilmaz,Rosalind A Segal
bioRxiv the preprint server for biology (2024)
Grace H. Hwang,Maria F. Pazyra-Murphy,Hyuk-Soo Seo,Sirano Dhe-Paganon, Sylwia A. Stopka, Marina Dipiazza, Nizhoni Sutter,Thomas W. Gero, Alison Volkert, Lincoln Ombelets, Georgia Dittemore,Matthew G. Rees,Melissa M. Ronan,Jennifer A. Roth,Nathalie Y. R. Agar,David A. Scott,Rosalind A. Segal
Cancer Researchno. 6 (2024): 872-886
Grace H. Hwang,Maria F. Pazyra-Murphy,Hyuk-Soo Seo,Sirano Dhe-Paganon, Sylwia A. Stopka, Marina DiPiazza, Nizhoni Sutter,Thomas W. Gero, Alison Volkert, Lincoln Ombelets, Georgia Dittemore,Matthew G. Rees,Melissa M. Ronan,Jennifer A. Roth,Nathalie Y.R. Agar,David A. Scott,Rosalind A. Segal
crossref(2024)
Maxwell P. Gold,Winnie Ong, Andrew M. Masteller,David R. Ghasemi, Julie Anne Galindo,Noel R. Park,Nhan C. Huynh, Aneesh Donde, Veronika Pister, Raul A. Saurez,Maria C. Vladoiu,Grace H. Hwang,Tanja Eisemann,Laura K. Donovan,Adam D. Walker, Joseph Benetatos, Christelle Dufour,Livia Garzia,Rosalind A. Segal,Robert J. Wechsler-Reya,Jill P. Mesirov, Andrey Korshunov, Kristian W. Pajtler,Scott L. Pomeroy,Olivier Ayrault,Shawn M. Davidson, Jennifer A. Cotter,Michael D. Taylor,Ernest Fraenkel
Nature Communicationsno. 1 (2024)
Grace H. Hwang,Maria F. Pazyra-Murphy,Hyuk-Soo Seo,Sirano Dhe-Paganon, Sylwia A. Stopka, Marina DiPiazza, Nizhoni Sutter,Thomas W. Gero, Alison Volkert, Lincoln Ombelets, Georgia Dittemore,Matthew G. Rees,Melissa M. Ronan,Jennifer A. Roth,Nathalie Y.R. Agar,David A. Scott,Rosalind A. Segal
crossref(2024)
Grace H. Hwang,Maria F. Pazyra‐Murphy,Hyuk-Soo Seo,Sirano Dhe‐Paganon, Sylwia A. Stopka, Marina DiPiazza, Nizhoni Sutter,Thomas W. Gero, Angela Volkert, Lincoln Ombelets, Georgia Dittemore,Matthew G. Rees,Melissa M. Ronan,Jennifer A. Roth,Nathalie Y.R. Agar,David A. Scott,Rosalind A. Segal
openalex(2024)
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作者统计
#Papers: 151
#Citation: 10315
H-Index: 48
G-Index: 101
Sociability: 7
Diversity: 0
Activity: 1
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