My research is focused on the mechanistic understanding of how the environment contributes to human health and disease. The overall goal of my research is to elucidate the complex gene-environment interactions that are critically involved in diseases relevant to public health. My goal is aided by the unprecedented and breathtaking development of new tools in modern genetics and genomics. These tools have the potential to advance our understanding of how gene-environment interactions impact health and are transforming the studies of environment health sciences and public health. Over the past ten years, I have developed a multi-faceted research program, in which I leverage my expertise in functional genetics and genomics to discover genes and genetic networks that, together with environmental exposures, contribute to the development of environmental diseases. I use a combination of molecular, cellular and biochemical approaches as well as animal models to further elucidate the underlying mechanisms contributing to these diseases. Through collaborations with epidemiologists, exposure scientists, and clinician colleagues, I also aim to understand the genetic basis of individual susceptibility to environmental exposure and to disease in the human population.