Characterization, function and regulation of the pituitary and renal growth hormone-releasing hormone receptor and its isoforms. Study of hypothalamo-pituitary somatotroph axis mechanisms of regulation, using animal model of successful aging (nutritional or hormonal interventions): molecular, cellular and functional approaches. Longitudinal study of a cohort of aged people, on nutrition as a determinant of successful aging, including nutrigenetics and nutrigenomics.