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个人简介
Our primary interests are in understanding the molecular underpinnings of vascular disease as well as assessing disease risk. We use a wide range of biochemical, molecular and physiological techniques to make primary observations in cell systems as well as preclinical models. Furthermore, we continue to extend our findings to human subjects in order to confirm their clinical applicability. Current research projects include:
Mechanisms regulating atherosclerosis and abdominal aortic aneurysm disease: While single genes can have dramatic effects in cellular biology, it is becoming increasingly clear that vascular disease (and health) is regulated by the coordinated expression of gene cassettes or pathways. By monitoring expression patterns of the entire genome simultaneously, we can begin to identify networks of genes that work in concert to affect disease progression. Moreover, this approach can often implicate specific nexus genes that are at the center of larger networks and/or participate in multiple pathways. Additionally, we are investigating the role microRNAs, a newly discovered class of small RNA molecues, in orchestrating the activity of multiple genes during the course of disease.
Role of insulin resistance: Reduced activity of the endogenous hormone, insulin, is now recognized as a cardinal feature of type 2 diabetes and an independent risk factor for cardiovascular disease. We have investigated the effects of insulin resistance in several tissues and have recently focused our attention on adipose tissue biology and how it relates to CVD. Long known as a storage vehicle for excess calories, the fat cell is now recognized to be a factory of different products that can not only affect local activity, but can circulate in the blood as hormones and regulate many biological processes. For example, we have recently reported that the novel hormone, apelin, is produced by fat tissue and has important effects upon insulin resistance, obesity and diabetes, all of which have significant implications for cardiovascular disease.
Mechanisms regulating atherosclerosis and abdominal aortic aneurysm disease: While single genes can have dramatic effects in cellular biology, it is becoming increasingly clear that vascular disease (and health) is regulated by the coordinated expression of gene cassettes or pathways. By monitoring expression patterns of the entire genome simultaneously, we can begin to identify networks of genes that work in concert to affect disease progression. Moreover, this approach can often implicate specific nexus genes that are at the center of larger networks and/or participate in multiple pathways. Additionally, we are investigating the role microRNAs, a newly discovered class of small RNA molecues, in orchestrating the activity of multiple genes during the course of disease.
Role of insulin resistance: Reduced activity of the endogenous hormone, insulin, is now recognized as a cardinal feature of type 2 diabetes and an independent risk factor for cardiovascular disease. We have investigated the effects of insulin resistance in several tissues and have recently focused our attention on adipose tissue biology and how it relates to CVD. Long known as a storage vehicle for excess calories, the fat cell is now recognized to be a factory of different products that can not only affect local activity, but can circulate in the blood as hormones and regulate many biological processes. For example, we have recently reported that the novel hormone, apelin, is produced by fat tissue and has important effects upon insulin resistance, obesity and diabetes, all of which have significant implications for cardiovascular disease.
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Arteriosclerosis, thrombosis, and vascular biologyno. 5 (2024): 1114-1123
Sai Zhang,Tobias Moll,Jasper Rubin-Sigler, Sharon Tu,Shuya Li,Enming Yuan, Menghui Liu, Afreen Butt,Calum Harvey, Sarah Gornall, Elham Alhalthli,Allan Shaw,
medRxiv : the preprint server for health sciences (2024)
Eleonora Scorletti,Yedidya Saiman, Sookyoung Jeon,Carolin V. Schneider, Delfin G. Buyco, Chelsea Lin,Blanca E. Himes,Clementina A. Mesaros,Marijana Vujkovic,Kate Townsend Creasy,Emma E. Furth,Jeffrey T. Billheimer,
JHEP REPORTSno. 1 (2024): 100902-100902
Zahra Azizi, Trisha Gupte,Pik Fang Kho, Kevin Nzenkue,Jiayan Zhou, Rodrigo Guarischi-Sousa,Daniel Panyard, Ming-Li Chen,Fahim Abbasi,Shoa Clarke,Philip Tsao,Themistocles L. Assimes
Journal of the American College of Cardiologyno. 13 (2024): 1699
ADVANCED SCIENCEno. 5 (2024): e2303664-e2303664
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Tselmen Daria, Hasan Alkhairo,Michael Levin,Scott M. Damrauer,Philip S. Tsao,James Priest,James Pirruccello, Justin B. Echouffo,Catherine Tcheandjieu
CIRCULATION (2023)
Pamela E Rios Coronado,Daniela Zanetti,Jiayan Zhou,Jeffrey A Naftaly, Pratima Prabala,Pik Fang Kho, Azalia M Martínez Jaimes,Austin T Hilliard,Saiju Pyarajan,Daniel Dochtermann,Million Veteran Program,Kyong-Mi Chang,
medRxiv : the preprint server for health sciences (2023)
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