基本信息
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Dr. Kern is engaged in both basic and clinical research related to obesity, metabolic syndrome, and diabetes. In clinical studies, Dr. Kern and his colleagues examine adipose tissue and muscle gene expression in relation to insulin resistance. Current themes involve a detailed evaluation of the role of tissue lipotoxicity and inflammation as important factors in obesity related insulin resistance. Current studies are examining the role of omega-3 fatty acids in metabolic syndrome as possible anti-inflammatory agents and as modulators of PPARg. Other studies are examining muscle and adipose tissue inflammation and fibrosis in response to exercise. The potential mechanisms of inflammation-mediated insulin resistance, and possible therapeutic interventions, are being studied both in vitro and in vivo.
Other research involves the gene expression of lipoprotein lipase (LPL), which is an important enzyme in adipose tissue that is involved in triglyceride metabolism, diabetes, and obesity. In recent studies, Dr. Kern’s lab identified components of an RNA binding complex that inhibited LPL translation in response to catecholamines. These data suggest a duel role for cAMP stimulation, resulting in a coordinated response to rapidly promote release of adipocyte lipid and inhibition of lipogenesis, all through posttranscriptional mechanisms.
Research Interests
Papers共 314 篇Author StatisticsCo-AuthorSimilar Experts
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Gabriella H Kalantar, Shubh Saraswat,Sara SantaCruz-Calvo, Fatemeh Gholamrezaeinejad,Aida Javidan,Madhur Agrawal,Rui Liu,Philip A Kern,Xiaohua Douglas Zhang,Barbara S Nikolajczyk
Nutrientsno. 10 (2024): 1404
PHYSIOLOGICAL REPORTSno. 3 (2024): e15924-e15924
bioRxiv : the preprint server for biology (2024): 219-220
Benjamin I Burke,Ahmed Ismaeel, Douglas E Long, Lauren A Depa, Peyton T Coburn,Jensen Goh, Tolulope P Saliu, Bonnie J Walton, Ivan J Vechetti,Bailey D Peck,Taylor R Valentino, C Brooks Mobley, Hasiyet Memetimin, Dandan Wang,Brian S Finlin,Philip A Kern,Charlotte A Peterson, John J McCarthy,Yuan Wen
JCI insight (2024)
Diabetesno. Supplement_1 (2024)
Douglas E Long, Alessandra J Mantuano,Amy L Confides, Benjamin F Miller,Philip A Kern,Timothy A Butterfield,Esther E Dupont-Versteegden
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCEno. 1 (2023)
Se-Hyung Park,Robert N. Helsley,Taghreed Fadhul,Jennifer L. S. Willoughby,Leila Noetzli,Ho-Chou Tu,Marie H. Solheim,Shiho Fujisaka, Hui Pan,Jonathan M. Dreyfuss,Joanna Bons,Jacob Rose,Christina D. King,Birgit Schilling,Aldons J. Lusis,Calvin Pan, Manoj Gupta,Rohit N. Kulkarni,Kevin Fitzgerald,Philip A. Kern,Senad Divanovic,C. Ronald Kahn,Samir Softic
Bryn J Pape,Philip A Kern
JCEM case reportsno. 6 (2023): luad132-luad132
Se-Hyung Park,Robert N. Helsley,Taghreed Fadhul,Jennifer L.S. Willoughby,Leila Noetzli,Ho-Chou Tu,Marie H. Solheim,Shiho Fujisaka, Hui Pan,Jonathan M. Dreyfuss,Joanna Bons,Jacob Rose,Christina D. King,Birgit Schilling,Aldons J. Lusis,Calvin Pan, Manoj Gupta,Rohit N. Kulkarni,Kevin Fitzgerald,Philip A. Kern,Senad Divanovic,C. Ronald Kahn,Samir Softic
bioRxiv the preprint server for biology (2023)
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Author Statistics
#Papers: 313
#Citation: 21587
H-Index: 64
G-Index: 145
Sociability: 7
Diversity: 0
Activity: 1
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