Patrick J Roberts - University of North Carolina at Chapel Hill

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INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors

Catherine Dietrich, Alec Trub,Antonio Ahn, Michael Taylor,Krutika Ambani,Keefe T. Chan,Kun-Hui Lu, Christabella A. Mahendra, Catherine Blyth,Rhiannon Coulson,Susanne Ramm,April C. Watt, Sunil Kumar Matsa,John Bisi,Jay Strum,Patrick Roberts,Shom Goel

CANCER DISCOVERYno. 3 (2024): 446-467

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INX-315, a potent and selective CDK2 inhibitor, demonstrates robust antitumor activity in CCNE1-amplified cancers

Alec G. Trub,John E. Bisi,Catherine Dietrich,Michael Taylor,Jay C. Strum,Shom Goel,Patrick J. Roberts

CANCER RESEARCHno. 7 (2023)

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Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

crossref（2023）

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Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

crossref（2023）

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Abstract 5994: INX-315, a potent and selective CDK2 inhibitor, demonstrates robust antitumor activity in CCNE1-amplified cancers

Alec G. Trub,John E. Bisi,Catherine A. Dietrich,Michael H. Taylor,Jay C. Strum,Shom Goel,Patrick Roberts

Cancer Research（2023）

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Clinicopathological Factors Affecting Breast Cancer Survival among Jamaican Women A Retrospective Review

Kemba A. Peters,Patrick O. Roberts,Rory K. Thomspson,Derek I. Mitchell,Derria Cornwall, Scott Goldson

ANNALS OF SURGICAL ONCOLOGY（2022）

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Trilaciclib Dose Selection: an Integrated Pharmacokinetic and Pharmacodynamic Analysis of Preclinical Data and Phase Ib/IIa Studies in Patients with Extensive-Stage Small Cell Lung Cancer

Chao Li,Lowell Hart,Taofeek K. Owonikoko,Raid Aljumaily,Caio Max Rocha Lima,Paul R. Conkling,Roy Timothy Webb,Robert M. Jotte,Steven Schuster,William J. Edenfield, Deborah A. Smith,Mark Sale,Patrick J. Roberts,Rajesh K. Malik,Jessica A. Sorrentino

Cancer chemotherapy and pharmacology（2021）

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Chemotherapy and CDK4/6 Inhibitors: Unexpected Bedfellows

Patrick J. Roberts,Vishnu Kumarasamy,Agnieszka K. Witkiewicz,Erik S. Knudsen

MOLECULAR CANCER THERAPEUTICS（2020）

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CDK4/6 Inhibition Enhances Antitumor Efficacy of Chemotherapy and Immune Checkpoint Inhibitor Combinations in Preclinical Models and Enhances T-cell Activation in Patients with SCLC Receiving Chemotherapy

Anne Y. Lai,Jessica A. Sorrentino,Konstantin H. Dragnev,Jared M. Weiss,Taofeek K. Owonikoko,Julie A. Rytlewski, Jill Hood,Zhao Yang,Rajesh K. Malik,Jay C. Strum,Patrick J. Roberts

Journal for ImmunoTherapy of Cancer（2020）

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Abstract 4732: CDK4/6 Inhibition with Lerociclib (G1T38) Enhances Response to PI3K or ERK Inhibitors in High-Throughput, Ex Vivo Pancreatic PDX Screens

Bingbing Dai, Daniel M. Freed,Jessica A. Sorrentino,Jithesh Jose Augustine,Tara G. Hughes,Ya'an Kang,Patrick J. Roberts,Jason B. Fleming,Michael P. Kim

Experimental and Molecular Therapeutics（2019）

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