Research Interest: To develop statistical methods and to innovatively apply statistical methods to the understanding to the genetic basis of human disease. In particular to: (a) robustly identify genomic drivers of oral cancer and obtain deep understanding of the biological underpinnings of oral cancer, with the goal providing precision genomic signatures of prediction and novel therapy; and (b) relate population genomic diversity, in conjunction with family and/or case-control studies, to various facets of common disease, e.g., splitting heritability of a disease to components of common genomic variation, rare genomic variation and environmental factors; response to drugs and vaccines, etc.